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Fusion gene ID: 20733 |
FusionGeneSummary for MAN1A1_MAGT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAN1A1_MAGT1 | Fusion gene ID: 20733 | Hgene | Tgene | Gene symbol | MAN1A1 | MAGT1 | Gene ID | 4121 | 84061 |
| Gene name | mannosidase alpha class 1A member 1 | magnesium transporter 1 | |
| Synonyms | HUMM3|HUMM9|MAN9 | IAP|MRX95|OST3B|PRO0756|XMEN|bA217H1.1 | |
| Cytomap | 6q22.31 | Xq21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mannosyl-oligosaccharide 1,2-alpha-mannosidase IAMan9-mannosidasealpha-1,2-mannosidase IAman(9)-alpha-mannosidaseprocessing alpha-1,2-mannosidase IA | magnesium transporter protein 1implantation-associated proteinoligosaccharyltransferase 3 homolog B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P33908 | Q9H0U3 | |
| Ensembl transtripts involved in fusion gene | ENST00000368468, ENST00000368466, | ENST00000358075, ENST00000373336, | |
| Fusion gene scores | * DoF score | 9 X 6 X 5=270 | 3 X 2 X 3=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/270*10)=-1.94753258010586 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAN1A1 [Title/Abstract] AND MAGT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-AB2F-01A | MAN1A1 | chr6 | 119611848 | - | MAGT1 | chrX | 77086392 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000368468 | ENST00000358075 | MAN1A1 | chr6 | 119611848 | - | MAGT1 | chrX | 77086392 | - |
| 5CDS-intron | ENST00000368468 | ENST00000373336 | MAN1A1 | chr6 | 119611848 | - | MAGT1 | chrX | 77086392 | - |
| In-frame | ENST00000368466 | ENST00000358075 | MAN1A1 | chr6 | 119611848 | - | MAGT1 | chrX | 77086392 | - |
| 5CDS-intron | ENST00000368466 | ENST00000373336 | MAN1A1 | chr6 | 119611848 | - | MAGT1 | chrX | 77086392 | - |
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FusionProtFeatures for MAN1A1_MAGT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAN1A1 | MAGT1 |