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Fusion gene ID: 20703 |
FusionGeneSummary for MAML2_EPHB2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAML2_EPHB2 | Fusion gene ID: 20703 | Hgene | Tgene | Gene symbol | MAML2 | EPHB2 | Gene ID | 84441 | 2048 |
| Gene name | mastermind like transcriptional coactivator 2 | EPH receptor B2 | |
| Synonyms | MAM-3|MAM2|MAM3|MLL-MAML2 | CAPB|DRT|EK5|EPHT3|ERK|Hek5|PCBC|Tyro5 | |
| Cytomap | 11q21 | 1p36.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mastermind-like protein 2mam-2mastermind-like 2 | ephrin type-B receptor 2EPH-like kinase 5developmentally-regulated Eph-related tyrosine kinaseelk-related tyrosine kinaseeph tyrosine kinase 3protein-tyrosine kinase HEK5renal carcinoma antigen NY-REN-47tyrosine-protein kinase TYRO5tyrosine-protei | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IZL2 | P29323 | |
| Ensembl transtripts involved in fusion gene | ENST00000524717, | ENST00000544305, ENST00000374630, ENST00000400191, ENST00000374632, ENST00000374627, ENST00000465676, | |
| Fusion gene scores | * DoF score | 11 X 8 X 5=440 | 9 X 8 X 4=288 |
| # samples | 12 | 11 | |
| ** MAII score | log2(12/440*10)=-1.87446911791614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/288*10)=-1.38856528791765 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAML2 [Title/Abstract] AND EPHB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAML2 | GO:0007219 | Notch signaling pathway | 12370315 |
| Hgene | MAML2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12370315 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF929677 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000524717 | ENST00000544305 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
| intron-intron | ENST00000524717 | ENST00000374630 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
| intron-intron | ENST00000524717 | ENST00000400191 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
| intron-intron | ENST00000524717 | ENST00000374632 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
| intron-intron | ENST00000524717 | ENST00000374627 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
| intron-intron | ENST00000524717 | ENST00000465676 | MAML2 | chr11 | 95756315 | - | EPHB2 | chr1 | 23235514 | + |
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FusionProtFeatures for MAML2_EPHB2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAML2 | EPHB2 |