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Fusion gene ID: 20699 |
FusionGeneSummary for MAML2_ATG13 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAML2_ATG13 | Fusion gene ID: 20699 | Hgene | Tgene | Gene symbol | MAML2 | ATG13 | Gene ID | 84441 | 9776 |
| Gene name | mastermind like transcriptional coactivator 2 | autophagy related 13 | |
| Synonyms | MAM-3|MAM2|MAM3|MLL-MAML2 | KIAA0652|PARATARG8 | |
| Cytomap | 11q21 | 11p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mastermind-like protein 2mam-2mastermind-like 2 | autophagy-related protein 13ATG13 autophagy related 13 homolog | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IZL2 | O75143 | |
| Ensembl transtripts involved in fusion gene | ENST00000524717, | ENST00000434074, ENST00000312040, ENST00000451945, ENST00000529655, ENST00000530500, ENST00000526508, ENST00000524625, ENST00000359513, ENST00000528494, ENST00000526485, | |
| Fusion gene scores | * DoF score | 11 X 8 X 5=440 | 3 X 2 X 3=18 |
| # samples | 12 | 3 | |
| ** MAII score | log2(12/440*10)=-1.87446911791614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MAML2 [Title/Abstract] AND ATG13 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAML2 | GO:0007219 | Notch signaling pathway | 12370315 |
| Hgene | MAML2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12370315 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-E1-A7Z2-01A | MAML2 | chr11 | 95825056 | - | ATG13 | chr11 | 46665829 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000524717 | ENST00000434074 | MAML2 | chr11 | 95825056 | - | ATG13 | chr11 | 46665829 | + |
| 5CDS-5UTR | ENST00000524717 | ENST00000312040 | MAML2 | chr11 | 95825056 | - | ATG13 | chr11 | 46665829 | + |
| 5CDS-5UTR | ENST00000524717 | ENST00000451945 | MAML2 | chr11 | 95825056 | - | ATG13 | chr11 | 46665829 | + |
| 5CDS-5UTR | ENST00000524717 | ENST00000529655 | MAML2 | chr11 | 95825056 | - | ATG13 | chr11 | 46665829 | + |
| 5CDS-intron | ENST00000524717 | ENST00000530500 | MAML2 | chr11 | 95825056 | - | ATG13 | chr11 | 46665829 | + |
| 5CDS-5UTR | ENST00000524717 | ENST00000526508 | MAML2 | chr11 | 95825056 | - | ATG13 | chr11 | 46665829 | + |
| 5CDS-5UTR | ENST00000524717 | ENST00000524625 | MAML2 | chr11 | 95825056 | - | ATG13 | chr11 | 46665829 | + |
| 5CDS-5UTR | ENST00000524717 | ENST00000359513 | MAML2 | chr11 | 95825056 | - | ATG13 | chr11 | 46665829 | + |
| 5CDS-5UTR | ENST00000524717 | ENST00000528494 | MAML2 | chr11 | 95825056 | - | ATG13 | chr11 | 46665829 | + |
| 5CDS-intron | ENST00000524717 | ENST00000526485 | MAML2 | chr11 | 95825056 | - | ATG13 | chr11 | 46665829 | + |
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FusionProtFeatures for MAML2_ATG13 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAML2 | ATG13 |