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Fusion gene ID: 20698 |
FusionGeneSummary for MAML2_ANKMY2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAML2_ANKMY2 | Fusion gene ID: 20698 | Hgene | Tgene | Gene symbol | MAML2 | ANKMY2 | Gene ID | 84441 | 57037 |
| Gene name | mastermind like transcriptional coactivator 2 | ankyrin repeat and MYND domain containing 2 | |
| Synonyms | MAM-3|MAM2|MAM3|MLL-MAML2 | ZMYND20 | |
| Cytomap | 11q21 | 7p21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mastermind-like protein 2mam-2mastermind-like 2 | ankyrin repeat and MYND domain-containing protein 2 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IZL2 | Q8IV38 | |
| Ensembl transtripts involved in fusion gene | ENST00000524717, | ENST00000306999, ENST00000421746, | |
| Fusion gene scores | * DoF score | 11 X 8 X 5=440 | 2 X 2 X 2=8 |
| # samples | 12 | 2 | |
| ** MAII score | log2(12/440*10)=-1.87446911791614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: MAML2 [Title/Abstract] AND ANKMY2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAML2 | GO:0007219 | Notch signaling pathway | 12370315 |
| Hgene | MAML2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12370315 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LGG | TCGA-TM-A84I-01A | MAML2 | chr11 | 96074547 | - | ANKMY2 | chr7 | 16666803 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000524717 | ENST00000306999 | MAML2 | chr11 | 96074547 | - | ANKMY2 | chr7 | 16666803 | - |
| 5CDS-5UTR | ENST00000524717 | ENST00000421746 | MAML2 | chr11 | 96074547 | - | ANKMY2 | chr7 | 16666803 | - |
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FusionProtFeatures for MAML2_ANKMY2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAML2 | ANKMY2 |