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Fusion gene ID: 20687 |
FusionGeneSummary for MALT1_CYP19A1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MALT1_CYP19A1 | Fusion gene ID: 20687 | Hgene | Tgene | Gene symbol | MALT1 | CYP19A1 | Gene ID | 10892 | 1588 |
| Gene name | MALT1 paracaspase | cytochrome P450 family 19 subfamily A member 1 | |
| Synonyms | IMD12|MLT|MLT1|PCASP1 | ARO|ARO1|CPV1|CYAR|CYP19|CYPXIX|P-450AROM | |
| Cytomap | 18q21.32 | 15q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mucosa-associated lymphoid tissue lymphoma translocation protein 1MALT lymphoma-associated translocationMALT1 proteasecaspase-like proteinmucosa associated lymphoid tissue lymphoma translocation gene 1paracaspaseparacaspase-1 | aromatasecytochrome P-450AROMcytochrome P450 19A1cytochrome P450, family 19, subfamily A, polypeptide 1cytochrome P450, subfamily XIX (aromatization of androgens)estrogen synthaseestrogen synthetaseflavoprotein-linked monooxygenasemicrosomal monoo | |
| Modification date | 20180529 | 20180520 | |
| UniProtAcc | Q9UDY8 | P11511 | |
| Ensembl transtripts involved in fusion gene | ENST00000348428, ENST00000345724, | ENST00000396402, ENST00000260433, ENST00000396404, ENST00000559878, ENST00000405913, ENST00000557858, ENST00000492852, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 9 X 9 X 3=243 |
| # samples | 5 | 11 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(11/243*10)=-1.14345279008112 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MALT1 [Title/Abstract] AND CYP19A1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MALT1 | GO:0006508 | proteolysis | 18223652 |
| Hgene | MALT1 | GO:0042981 | regulation of apoptotic process | 12819136 |
| Hgene | MALT1 | GO:0050852 | T cell receptor signaling pathway | 15125833 |
| Hgene | MALT1 | GO:0051168 | nuclear export | 16123224 |
| Hgene | MALT1 | GO:0051259 | protein complex oligomerization | 15125833 |
| Tgene | CYP19A1 | GO:0006710 | androgen catabolic process | 26482249 |
| Tgene | CYP19A1 | GO:2000866 | positive regulation of estradiol secretion | 26482249 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF888866 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + | ||
| ChiTaRS3.1 | BF889014 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000348428 | ENST00000396402 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000348428 | ENST00000260433 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000348428 | ENST00000396404 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000348428 | ENST00000559878 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000348428 | ENST00000405913 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000348428 | ENST00000557858 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000348428 | ENST00000492852 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000345724 | ENST00000396402 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000345724 | ENST00000260433 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000345724 | ENST00000396404 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000345724 | ENST00000559878 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000345724 | ENST00000405913 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000345724 | ENST00000557858 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
| intron-intron | ENST00000345724 | ENST00000492852 | MALT1 | chr18 | 56368536 | + | CYP19A1 | chr15 | 51506489 | + |
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FusionProtFeatures for MALT1_CYP19A1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MALT1 | CYP19A1 |