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Fusion gene ID: 20667 |
FusionGeneSummary for MALAT1_SPRED1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MALAT1_SPRED1 | Fusion gene ID: 20667 | Hgene | Tgene | Gene symbol | MALAT1 | SPRED1 | Gene ID | 378938 | 161742 |
| Gene name | metastasis associated lung adenocarcinoma transcript 1 | sprouty related EVH1 domain containing 1 | |
| Synonyms | HCN|LINC00047|NCRNA00047|NEAT2|PRO2853 | NFLS|PPP1R147|hSpred1|spred-1 | |
| Cytomap | 11q13.1 | 15q14 | |
| Type of gene | ncRNA | protein-coding | |
| Description | hepcarcinlong intergenic non-protein coding RNA 47metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)nuclear enriched abundant transcript 2nuclear paraspeckle assembly transcript 2 (non-protein coding) | sprouty-related, EVH1 domain-containing protein 1protein phosphatase 1, regulatory subunit 147suppressor of Ras/MAPK activation | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | Q7Z699 | ||
| Ensembl transtripts involved in fusion gene | ENST00000534336, | ENST00000299084, ENST00000561205, | |
| Fusion gene scores | * DoF score | 83 X 128 X 5=53120 | 5 X 5 X 2=50 |
| # samples | 141 | 6 | |
| ** MAII score | log2(141/53120*10)=-5.23548807894813 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/50*10)=0.263034405833794 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MALAT1 [Title/Abstract] AND SPRED1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SPRED1 | GO:0006469 | negative regulation of protein kinase activity | 18216281 |
| Tgene | SPRED1 | GO:0010923 | negative regulation of phosphatase activity | 19389623 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA774258 | MALAT1 | chr11 | 65269819 | + | SPRED1 | chr15 | 38643887 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000534336 | ENST00000299084 | MALAT1 | chr11 | 65269819 | + | SPRED1 | chr15 | 38643887 | + |
| 3UTR-intron | ENST00000534336 | ENST00000561205 | MALAT1 | chr11 | 65269819 | + | SPRED1 | chr15 | 38643887 | + |
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FusionProtFeatures for MALAT1_SPRED1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MALAT1 | SPRED1 |