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Fusion gene ID: 20643 |
FusionGeneSummary for MALAT1_MX2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MALAT1_MX2 | Fusion gene ID: 20643 | Hgene | Tgene | Gene symbol | MALAT1 | MX2 | Gene ID | 378938 | 4600 |
| Gene name | metastasis associated lung adenocarcinoma transcript 1 | MX dynamin like GTPase 2 | |
| Synonyms | HCN|LINC00047|NCRNA00047|NEAT2|PRO2853 | MXB | |
| Cytomap | 11q13.1 | 21q22.3 | |
| Type of gene | ncRNA | protein-coding | |
| Description | hepcarcinlong intergenic non-protein coding RNA 47metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)nuclear enriched abundant transcript 2nuclear paraspeckle assembly transcript 2 (non-protein coding) | interferon-induced GTP-binding protein Mx2interferon-regulated resistance GTP-binding protein MXBmyxovirus (influenza virus) resistance 2myxovirus resistance protein 2p78-related proteinsecond interferon-induced protein p78 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P20592 | ||
| Ensembl transtripts involved in fusion gene | ENST00000534336, | ENST00000330714, ENST00000543692, ENST00000496774, | |
| Fusion gene scores | * DoF score | 83 X 128 X 5=53120 | 4 X 3 X 3=36 |
| # samples | 141 | 5 | |
| ** MAII score | log2(141/53120*10)=-5.23548807894813 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: MALAT1 [Title/Abstract] AND MX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MX2 | GO:0009615 | response to virus | 24048477 |
| Tgene | MX2 | GO:0035455 | response to interferon-alpha | 24121441 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE763753 | MALAT1 | chr11 | 65268341 | - | MX2 | chr21 | 42737892 | + | ||
| ChiTaRS3.1 | BE763816 | MALAT1 | chr11 | 65268341 | - | MX2 | chr21 | 42737892 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-intron | ENST00000534336 | ENST00000330714 | MALAT1 | chr11 | 65268341 | - | MX2 | chr21 | 42737892 | + |
| 3UTR-intron | ENST00000534336 | ENST00000543692 | MALAT1 | chr11 | 65268341 | - | MX2 | chr21 | 42737892 | + |
| 3UTR-intron | ENST00000534336 | ENST00000496774 | MALAT1 | chr11 | 65268341 | - | MX2 | chr21 | 42737892 | + |
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FusionProtFeatures for MALAT1_MX2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MALAT1 | MX2 |