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Fusion gene ID: 20626 |
FusionGeneSummary for MALAT1_HSP90AA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MALAT1_HSP90AA1 | Fusion gene ID: 20626 | Hgene | Tgene | Gene symbol | MALAT1 | HSP90AA1 | Gene ID | 378938 | 3320 |
| Gene name | metastasis associated lung adenocarcinoma transcript 1 | heat shock protein 90 alpha family class A member 1 | |
| Synonyms | HCN|LINC00047|NCRNA00047|NEAT2|PRO2853 | EL52|HEL-S-65p|HSP86|HSP89A|HSP90A|HSP90N|HSPC1|HSPCA|HSPCAL1|HSPCAL4|HSPN|Hsp103|Hsp89|Hsp90|LAP-2|LAP2 | |
| Cytomap | 11q13.1 | 14q32.31 | |
| Type of gene | ncRNA | protein-coding | |
| Description | hepcarcinlong intergenic non-protein coding RNA 47metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)nuclear enriched abundant transcript 2nuclear paraspeckle assembly transcript 2 (non-protein coding) | heat shock protein HSP 90-alphaHSP 86LPS-associated protein 2epididymis luminal secretory protein 52epididymis secretory sperm binding protein Li 65pheat shock 86 kDaheat shock 90kD protein 1, alphaheat shock 90kD protein 1, alpha-like 4heat shock | |
| Modification date | 20180527 | 20180527 | |
| UniProtAcc | P07900 | ||
| Ensembl transtripts involved in fusion gene | ENST00000534336, | ENST00000216281, ENST00000334701, ENST00000441629, ENST00000558600, | |
| Fusion gene scores | * DoF score | 83 X 128 X 5=53120 | 18 X 19 X 6=2052 |
| # samples | 141 | 23 | |
| ** MAII score | log2(141/53120*10)=-5.23548807894813 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(23/2052*10)=-3.15732496466268 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MALAT1 [Title/Abstract] AND HSP90AA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | HSP90AA1 | GO:0001934 | positive regulation of protein phosphorylation | 19363271 |
| Tgene | HSP90AA1 | GO:0007004 | telomere maintenance via telomerase | 10197982 |
| Tgene | HSP90AA1 | GO:0031396 | regulation of protein ubiquitination | 16809764 |
| Tgene | HSP90AA1 | GO:0032273 | positive regulation of protein polymerization | 19363271 |
| Tgene | HSP90AA1 | GO:0045040 | protein import into mitochondrial outer membrane | 15644312 |
| Tgene | HSP90AA1 | GO:0051131 | chaperone-mediated protein complex assembly | 15644312 |
| Tgene | HSP90AA1 | GO:0051973 | positive regulation of telomerase activity | 10197982 |
| Tgene | HSP90AA1 | GO:1902949 | positive regulation of tau-protein kinase activity | 19363271 |
| Tgene | HSP90AA1 | GO:1905323 | telomerase holoenzyme complex assembly | 10197982 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | D87666 | MALAT1 | chr11 | 65267197 | + | HSP90AA1 | chr14 | 102549512 | - | ||
| ChiTaRS3.1 | CB135099 | MALAT1 | chr11 | 65267380 | + | HSP90AA1 | chr14 | 102551727 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000534336 | ENST00000216281 | MALAT1 | chr11 | 65267197 | + | HSP90AA1 | chr14 | 102549512 | - |
| 3UTR-3CDS | ENST00000534336 | ENST00000334701 | MALAT1 | chr11 | 65267197 | + | HSP90AA1 | chr14 | 102549512 | - |
| 3UTR-3CDS | ENST00000534336 | ENST00000441629 | MALAT1 | chr11 | 65267197 | + | HSP90AA1 | chr14 | 102549512 | - |
| 3UTR-intron | ENST00000534336 | ENST00000558600 | MALAT1 | chr11 | 65267197 | + | HSP90AA1 | chr14 | 102549512 | - |
| 3UTR-3CDS | ENST00000534336 | ENST00000216281 | MALAT1 | chr11 | 65267380 | + | HSP90AA1 | chr14 | 102551727 | - |
| 3UTR-3CDS | ENST00000534336 | ENST00000334701 | MALAT1 | chr11 | 65267380 | + | HSP90AA1 | chr14 | 102551727 | - |
| 3UTR-3CDS | ENST00000534336 | ENST00000441629 | MALAT1 | chr11 | 65267380 | + | HSP90AA1 | chr14 | 102551727 | - |
| 3UTR-intron | ENST00000534336 | ENST00000558600 | MALAT1 | chr11 | 65267380 | + | HSP90AA1 | chr14 | 102551727 | - |
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FusionProtFeatures for MALAT1_HSP90AA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MALAT1 | HSP90AA1 |