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Fusion gene ID: 20586 |
FusionGeneSummary for MAGI3_DENND5A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAGI3_DENND5A | Fusion gene ID: 20586 | Hgene | Tgene | Gene symbol | MAGI3 | DENND5A | Gene ID | 260425 | 23258 |
| Gene name | membrane associated guanylate kinase, WW and PDZ domain containing 3 | DENN domain containing 5A | |
| Synonyms | MAGI-3|dJ730K3.2 | EIEE49|RAB6IP1 | |
| Cytomap | 1p13.2 | 11p15.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3membrane-associated guanylate kinase inverted 3membrane-associated guanylate kinase-related 3 | DENN domain-containing protein 5ADENN/MADD domain containing 5ARAB6 interacting protein 1rab6-interacting protein 1 | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q5TCQ9 | Q6IQ26 | |
| Ensembl transtripts involved in fusion gene | ENST00000369617, ENST00000307546, ENST00000369615, ENST00000369611, ENST00000486456, | ENST00000328194, ENST00000530044, ENST00000527700, ENST00000526523, | |
| Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 9 X 10 X 5=450 |
| # samples | 5 | 10 | |
| ** MAII score | log2(5/45*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/450*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAGI3 [Title/Abstract] AND DENND5A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | OV | TCGA-24-1549-01A | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000369617 | ENST00000328194 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| Frame-shift | ENST00000369617 | ENST00000530044 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| Frame-shift | ENST00000369617 | ENST00000527700 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| 5CDS-intron | ENST00000369617 | ENST00000526523 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| In-frame | ENST00000307546 | ENST00000328194 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| Frame-shift | ENST00000307546 | ENST00000530044 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| Frame-shift | ENST00000307546 | ENST00000527700 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| 5CDS-intron | ENST00000307546 | ENST00000526523 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| In-frame | ENST00000369615 | ENST00000328194 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| Frame-shift | ENST00000369615 | ENST00000530044 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| Frame-shift | ENST00000369615 | ENST00000527700 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| 5CDS-intron | ENST00000369615 | ENST00000526523 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| In-frame | ENST00000369611 | ENST00000328194 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| Frame-shift | ENST00000369611 | ENST00000530044 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| Frame-shift | ENST00000369611 | ENST00000527700 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| 5CDS-intron | ENST00000369611 | ENST00000526523 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| 3UTR-3CDS | ENST00000486456 | ENST00000328194 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| 3UTR-3CDS | ENST00000486456 | ENST00000530044 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| 3UTR-3CDS | ENST00000486456 | ENST00000527700 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
| 3UTR-intron | ENST00000486456 | ENST00000526523 | MAGI3 | chr1 | 113933971 | + | DENND5A | chr11 | 9161401 | - |
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FusionProtFeatures for MAGI3_DENND5A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAGI3 | DENND5A |