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Fusion gene ID: 20582 |
FusionGeneSummary for MAGI2_CTNNA2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MAGI2_CTNNA2 | Fusion gene ID: 20582 | Hgene | Tgene | Gene symbol | MAGI2 | CTNNA2 | Gene ID | 9863 | 1496 |
| Gene name | membrane associated guanylate kinase, WW and PDZ domain containing 2 | catenin alpha 2 | |
| Synonyms | ACVRIP1|AIP-1|AIP1|ARIP1|MAGI-2|SSCAM | CAP-R|CAPR|CT114|CTNR | |
| Cytomap | 7q21.11 | 2p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2activin receptor interacting protein 1atrophin-1-interacting protein 1atrophin-1-interacting protein Amembrane-associated guanylate kinase inverted 2 | catenin alpha-2alpha-N-cateninalpha-catenin-related proteincadherin-associated protein, relatedcancer/testis antigen 114catenin (cadherin-associated protein), alpha 2 | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q86UL8 | P26232 | |
| Ensembl transtripts involved in fusion gene | ENST00000419488, ENST00000354212, ENST00000522391, ENST00000536571, ENST00000535697, ENST00000517762, | ENST00000466387, ENST00000496558, ENST00000361291, ENST00000402739, ENST00000540488, ENST00000541047, ENST00000343114, ENST00000496251, ENST00000409266, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 15 X 12 X 9=1620 |
| # samples | 3 | 15 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(15/1620*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MAGI2 [Title/Abstract] AND CTNNA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MAGI2 | GO:0002092 | positive regulation of receptor internalization | 11526121 |
| Hgene | MAGI2 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity | 10760291 |
| Hgene | MAGI2 | GO:0051898 | negative regulation of protein kinase B signaling | 10760291 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA202182 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000419488 | ENST00000466387 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000419488 | ENST00000496558 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000419488 | ENST00000361291 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000419488 | ENST00000402739 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000419488 | ENST00000540488 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000419488 | ENST00000541047 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000419488 | ENST00000343114 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-intron | ENST00000419488 | ENST00000496251 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-intron | ENST00000419488 | ENST00000409266 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000354212 | ENST00000466387 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000354212 | ENST00000496558 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000354212 | ENST00000361291 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000354212 | ENST00000402739 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000354212 | ENST00000540488 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000354212 | ENST00000541047 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000354212 | ENST00000343114 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-intron | ENST00000354212 | ENST00000496251 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-intron | ENST00000354212 | ENST00000409266 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000522391 | ENST00000466387 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000522391 | ENST00000496558 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000522391 | ENST00000361291 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000522391 | ENST00000402739 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000522391 | ENST00000540488 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000522391 | ENST00000541047 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000522391 | ENST00000343114 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-intron | ENST00000522391 | ENST00000496251 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-intron | ENST00000522391 | ENST00000409266 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000536571 | ENST00000466387 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000536571 | ENST00000496558 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000536571 | ENST00000361291 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000536571 | ENST00000402739 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000536571 | ENST00000540488 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000536571 | ENST00000541047 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000536571 | ENST00000343114 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-intron | ENST00000536571 | ENST00000496251 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-intron | ENST00000536571 | ENST00000409266 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000535697 | ENST00000466387 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000535697 | ENST00000496558 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000535697 | ENST00000361291 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000535697 | ENST00000402739 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000535697 | ENST00000540488 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000535697 | ENST00000541047 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-3CDS | ENST00000535697 | ENST00000343114 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-intron | ENST00000535697 | ENST00000496251 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| 5UTR-intron | ENST00000535697 | ENST00000409266 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000517762 | ENST00000466387 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000517762 | ENST00000496558 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000517762 | ENST00000361291 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000517762 | ENST00000402739 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000517762 | ENST00000540488 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000517762 | ENST00000541047 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-3CDS | ENST00000517762 | ENST00000343114 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-intron | ENST00000517762 | ENST00000496251 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
| intron-intron | ENST00000517762 | ENST00000409266 | MAGI2 | chr7 | 78400167 | - | CTNNA2 | chr2 | 80620333 | + |
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FusionProtFeatures for MAGI2_CTNNA2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| MAGI2 | CTNNA2 |