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Fusion gene ID: 20482 |
FusionGeneSummary for LYZ_SMG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LYZ_SMG1 | Fusion gene ID: 20482 | Hgene | Tgene | Gene symbol | LYZ | SMG1 | Gene ID | 4069 | 23049 |
| Gene name | lysozyme | SMG1, nonsense mediated mRNA decay associated PI3K related kinase | |
| Synonyms | LYZF1|LZM | 61E3.4|ATX|LIP | |
| Cytomap | 12q15 | 16p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1 | serine/threonine-protein kinase SMG1PI-3-kinase-related kinase SMG-1SMG1 phosphatidylinositol 3-kinase-related kinaselambda-interacting proteinlambda/iota protein kinase C-interacting proteinsmg-1 homolog, phosphatidylinositol 3-kinase-related kinase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P61626 | Q96Q15 | |
| Ensembl transtripts involved in fusion gene | ENST00000261267, ENST00000549690, ENST00000548839, | ENST00000389467, ENST00000446231, ENST00000565224, ENST00000567737, | |
| Fusion gene scores | * DoF score | 19 X 13 X 6=1482 | 7 X 8 X 4=224 |
| # samples | 23 | 8 | |
| ** MAII score | log2(23/1482*10)=-2.68783968136146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/224*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LYZ [Title/Abstract] AND SMG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LYZ | GO:0031640 | killing of cells of other organism | 9727055 |
| Hgene | LYZ | GO:0042742 | defense response to bacterium | 21093056 |
| Hgene | LYZ | GO:0050830 | defense response to Gram-positive bacterium | 21093056 |
| Tgene | SMG1 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | 11544179 |
| Tgene | SMG1 | GO:0018105 | peptidyl-serine phosphorylation | 11544179|15175154 |
| Tgene | SMG1 | GO:0046777 | protein autophosphorylation | 11331269|11544179 |
| Tgene | SMG1 | GO:0046854 | phosphatidylinositol phosphorylation | 11331269 |
| Tgene | SMG1 | GO:2001020 | regulation of response to DNA damage stimulus | 15175154 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LAML | TCGA-AB-2875-03A | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| TCGA | LD | LAML | TCGA-AB-2911-03A | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000261267 | ENST00000389467 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| 3UTR-3UTR | ENST00000261267 | ENST00000446231 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| 3UTR-intron | ENST00000261267 | ENST00000565224 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| 3UTR-intron | ENST00000261267 | ENST00000567737 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| 3UTR-3UTR | ENST00000549690 | ENST00000389467 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| 3UTR-3UTR | ENST00000549690 | ENST00000446231 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| 3UTR-intron | ENST00000549690 | ENST00000565224 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| 3UTR-intron | ENST00000549690 | ENST00000567737 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| intron-3UTR | ENST00000548839 | ENST00000389467 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| intron-3UTR | ENST00000548839 | ENST00000446231 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| intron-intron | ENST00000548839 | ENST00000565224 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| intron-intron | ENST00000548839 | ENST00000567737 | LYZ | chr12 | 69747265 | + | SMG1 | chr16 | 18819127 | - |
| 3UTR-3UTR | ENST00000261267 | ENST00000389467 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| 3UTR-3UTR | ENST00000261267 | ENST00000446231 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| 3UTR-intron | ENST00000261267 | ENST00000565224 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| 3UTR-intron | ENST00000261267 | ENST00000567737 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| 3UTR-3UTR | ENST00000549690 | ENST00000389467 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| 3UTR-3UTR | ENST00000549690 | ENST00000446231 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| 3UTR-intron | ENST00000549690 | ENST00000565224 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| 3UTR-intron | ENST00000549690 | ENST00000567737 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| intron-3UTR | ENST00000548839 | ENST00000389467 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| intron-3UTR | ENST00000548839 | ENST00000446231 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| intron-intron | ENST00000548839 | ENST00000565224 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
| intron-intron | ENST00000548839 | ENST00000567737 | LYZ | chr12 | 69747259 | + | SMG1 | chr16 | 18819133 | - |
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FusionProtFeatures for LYZ_SMG1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LYZ | SMG1 |