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Fusion gene ID: 20364 |
FusionGeneSummary for LTBP1_ZDHHC2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LTBP1_ZDHHC2 | Fusion gene ID: 20364 | Hgene | Tgene | Gene symbol | LTBP1 | ZDHHC2 | Gene ID | 4052 | 51201 |
| Gene name | latent transforming growth factor beta binding protein 1 | zinc finger DHHC-type containing 2 | |
| Synonyms | - | DHHC2|ZNF372 | |
| Cytomap | 2p22.3 | 8p22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | latent-transforming growth factor beta-binding protein 1LTBP-1TGF-beta1-BP-1transforming growth factor beta-1-binding protein 1 | palmitoyltransferase ZDHHC2DHHC-2reamrecreduced expression associated with metastasis proteinreduced expression in cancer proteintestis tissue sperm-binding protein Li 56ezinc finger DHHC domain-containing protein 2zinc finger protein 372zinc fin | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q14766 | Q9UIJ5 | |
| Ensembl transtripts involved in fusion gene | ENST00000404816, ENST00000354476, ENST00000390003, ENST00000418533, ENST00000402934, ENST00000404525, ENST00000407925, ENST00000272273, ENST00000498013, | ENST00000262096, | |
| Fusion gene scores | * DoF score | 8 X 7 X 9=504 | 5 X 5 X 4=100 |
| # samples | 15 | 5 | |
| ** MAII score | log2(15/504*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LTBP1 [Title/Abstract] AND ZDHHC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ZDHHC2 | GO:0018345 | protein palmitoylation | 23034182 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-AR-A0TU-01A | LTBP1 | chr2 | 33540336 | + | ZDHHC2 | chr8 | 17042298 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000404816 | ENST00000262096 | LTBP1 | chr2 | 33540336 | + | ZDHHC2 | chr8 | 17042298 | + |
| In-frame | ENST00000354476 | ENST00000262096 | LTBP1 | chr2 | 33540336 | + | ZDHHC2 | chr8 | 17042298 | + |
| In-frame | ENST00000390003 | ENST00000262096 | LTBP1 | chr2 | 33540336 | + | ZDHHC2 | chr8 | 17042298 | + |
| In-frame | ENST00000418533 | ENST00000262096 | LTBP1 | chr2 | 33540336 | + | ZDHHC2 | chr8 | 17042298 | + |
| In-frame | ENST00000402934 | ENST00000262096 | LTBP1 | chr2 | 33540336 | + | ZDHHC2 | chr8 | 17042298 | + |
| In-frame | ENST00000404525 | ENST00000262096 | LTBP1 | chr2 | 33540336 | + | ZDHHC2 | chr8 | 17042298 | + |
| In-frame | ENST00000407925 | ENST00000262096 | LTBP1 | chr2 | 33540336 | + | ZDHHC2 | chr8 | 17042298 | + |
| In-frame | ENST00000272273 | ENST00000262096 | LTBP1 | chr2 | 33540336 | + | ZDHHC2 | chr8 | 17042298 | + |
| intron-3CDS | ENST00000498013 | ENST00000262096 | LTBP1 | chr2 | 33540336 | + | ZDHHC2 | chr8 | 17042298 | + |
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FusionProtFeatures for LTBP1_ZDHHC2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LTBP1 | ZDHHC2 |