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Fusion gene ID: 2036 |
FusionGeneSummary for AP1M1_ZNF93 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: AP1M1_ZNF93 | Fusion gene ID: 2036 | Hgene | Tgene | Gene symbol | AP1M1 | ZNF93 | Gene ID | 8907 | 81931 |
| Gene name | adaptor related protein complex 1 subunit mu 1 | zinc finger protein 93 | |
| Synonyms | AP47|CLAPM2|CLTNM|MU-1A | HPF34|HTF34|TF34|ZNF505 | |
| Cytomap | 19p13.11 | 19p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | AP-1 complex subunit mu-1AP-mu chain family member mu1AHA1 47 kDa subunitadapter-related protein complex 1 subunit mu-1adaptor protein complex AP-1 mu-1 subunitadaptor protein complex AP-1 subunit mu-1adaptor related protein complex 1 mu 1 subunitc | zinc finger protein 93zinc finger protein 505zinc finger protein HTF34 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9BXS5 | P35789 | |
| Ensembl transtripts involved in fusion gene | ENST00000291439, ENST00000541844, ENST00000590756, ENST00000429941, ENST00000444449, | ENST00000592613, ENST00000591366, ENST00000592160, ENST00000343769, | |
| Fusion gene scores | * DoF score | 4 X 1 X 3=12 | 3 X 2 X 3=18 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: AP1M1 [Title/Abstract] AND ZNF93 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ZNF93 | GO:0045892 | negative regulation of transcription, DNA-templated | 25274305 |
| Tgene | ZNF93 | GO:0070895 | negative regulation of transposon integration | 25274305 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-BH-A0BR-01A | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000291439 | ENST00000592613 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000291439 | ENST00000591366 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000291439 | ENST00000592160 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000291439 | ENST00000343769 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000541844 | ENST00000592613 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000541844 | ENST00000591366 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000541844 | ENST00000592160 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000541844 | ENST00000343769 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000590756 | ENST00000592613 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000590756 | ENST00000591366 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000590756 | ENST00000592160 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000590756 | ENST00000343769 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000429941 | ENST00000592613 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000429941 | ENST00000591366 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000429941 | ENST00000592160 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000429941 | ENST00000343769 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000444449 | ENST00000592613 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000444449 | ENST00000591366 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000444449 | ENST00000592160 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
| 5CDS-intron | ENST00000444449 | ENST00000343769 | AP1M1 | chr19 | 16319988 | + | ZNF93 | chr19 | 20043991 | + |
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FusionProtFeatures for AP1M1_ZNF93 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AP1M1 | ZNF93 |