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Fusion gene ID: 20355 |
FusionGeneSummary for LTA4H_SLC25A24 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LTA4H_SLC25A24 | Fusion gene ID: 20355 | Hgene | Tgene | Gene symbol | LTA4H | SLC25A24 | Gene ID | 4048 | 29957 |
| Gene name | leukotriene A4 hydrolase | solute carrier family 25 member 24 | |
| Synonyms | - | APC1|SCAMC-1|SCAMC1 | |
| Cytomap | 12q23.1 | 1p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leukotriene A-4 hydrolaseLTA-4 hydrolasetesticular secretory protein Li 27 | calcium-binding mitochondrial carrier protein SCaMC-1calcium-binding transportermitochondrial ATP-Mg/Pi carrier protein 1mitochondrial Ca(2+)-dependent solute carrier protein 1short calcium-binding mitochondrial carrier 1small calcium-binding mitocho | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P09960 | Q6NUK1 | |
| Ensembl transtripts involved in fusion gene | ENST00000228740, ENST00000552789, ENST00000413268, ENST00000548375, | ENST00000565488, ENST00000370041, ENST00000569674, | |
| Fusion gene scores | * DoF score | 6 X 5 X 3=90 | 2 X 2 X 2=8 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LTA4H [Title/Abstract] AND SLC25A24 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LTA4H | GO:0019370 | leukotriene biosynthetic process | 9774412|15078870 |
| Hgene | LTA4H | GO:0043171 | peptide catabolic process | 9774412|15078870|18804029 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-BR-A4J6-01A | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000228740 | ENST00000565488 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| In-frame | ENST00000228740 | ENST00000370041 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| 5CDS-intron | ENST00000228740 | ENST00000569674 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| In-frame | ENST00000552789 | ENST00000565488 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| In-frame | ENST00000552789 | ENST00000370041 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| 5CDS-intron | ENST00000552789 | ENST00000569674 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| Frame-shift | ENST00000413268 | ENST00000565488 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| Frame-shift | ENST00000413268 | ENST00000370041 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| 5CDS-intron | ENST00000413268 | ENST00000569674 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| 5UTR-3CDS | ENST00000548375 | ENST00000565488 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| 5UTR-3CDS | ENST00000548375 | ENST00000370041 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
| 5UTR-intron | ENST00000548375 | ENST00000569674 | LTA4H | chr12 | 96402872 | - | SLC25A24 | chr1 | 108686332 | - |
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FusionProtFeatures for LTA4H_SLC25A24 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LTA4H | SLC25A24 |