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Fusion gene ID: 20232 |
FusionGeneSummary for LRRC40_ACAD11 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRRC40_ACAD11 | Fusion gene ID: 20232 | Hgene | Tgene | Gene symbol | LRRC40 | ACAD11 | Gene ID | 55631 | 84129 |
| Gene name | leucine rich repeat containing 40 | acyl-CoA dehydrogenase family member 11 | |
| Synonyms | dJ677H15.1 | ACAD-11 | |
| Cytomap | 1p31.1 | 3q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leucine-rich repeat-containing protein 40testicular tissue protein Li 109 | acyl-CoA dehydrogenase family member 11acyl-Coenzyme A dehydrogenase family, member 11 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9H9A6 | Q709F0 | |
| Ensembl transtripts involved in fusion gene | ENST00000370952, | ENST00000355458, ENST00000264990, ENST00000545291, ENST00000481970, ENST00000489991, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 3=27 |
| # samples | 2 | 3 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LRRC40 [Title/Abstract] AND ACAD11 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ACAD11 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase | 21237683 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DA565124 | LRRC40 | chr1 | 70640816 | - | ACAD11 | chr3 | 132316124 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000370952 | ENST00000355458 | LRRC40 | chr1 | 70640816 | - | ACAD11 | chr3 | 132316124 | + |
| intron-intron | ENST00000370952 | ENST00000264990 | LRRC40 | chr1 | 70640816 | - | ACAD11 | chr3 | 132316124 | + |
| intron-intron | ENST00000370952 | ENST00000545291 | LRRC40 | chr1 | 70640816 | - | ACAD11 | chr3 | 132316124 | + |
| intron-intron | ENST00000370952 | ENST00000481970 | LRRC40 | chr1 | 70640816 | - | ACAD11 | chr3 | 132316124 | + |
| intron-intron | ENST00000370952 | ENST00000489991 | LRRC40 | chr1 | 70640816 | - | ACAD11 | chr3 | 132316124 | + |
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FusionProtFeatures for LRRC40_ACAD11 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRRC40 | ACAD11 |