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Fusion gene ID: 20207 |
FusionGeneSummary for LRRC1_FRY |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRRC1_FRY | Fusion gene ID: 20207 | Hgene | Tgene | Gene symbol | LRRC1 | FRY | Gene ID | 55227 | 10129 |
| Gene name | leucine rich repeat containing 1 | FRY microtubule binding protein | |
| Synonyms | LANO|dJ523E19.1 | 13CDNA73|214K23.2|C13orf14|CG003|bA207N4.2|bA37E23.1 | |
| Cytomap | 6p12.1 | 13q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leucine-rich repeat-containing protein 1LANO adapter proteinLAP (leucine-rich repeats and PDZ) and no PDZ proteinLAP and no PDZ protein | protein furry homologWUGSC:H_2G3A.1furry homolog | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9BTT6 | Q5TBA9 | |
| Ensembl transtripts involved in fusion gene | ENST00000370888, ENST00000370882, | ENST00000380250, ENST00000463566, ENST00000542859, ENST00000380217, | |
| Fusion gene scores | * DoF score | 7 X 3 X 6=126 | 2 X 2 X 2=8 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/126*10)=-0.333423733725192 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LRRC1 [Title/Abstract] AND FRY [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-C8-A1HG-01A | LRRC1 | chr6 | 53660213 | + | FRY | chr13 | 32705809 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000370888 | ENST00000380250 | LRRC1 | chr6 | 53660213 | + | FRY | chr13 | 32705809 | + |
| 5CDS-intron | ENST00000370888 | ENST00000463566 | LRRC1 | chr6 | 53660213 | + | FRY | chr13 | 32705809 | + |
| 5CDS-intron | ENST00000370888 | ENST00000542859 | LRRC1 | chr6 | 53660213 | + | FRY | chr13 | 32705809 | + |
| 5CDS-intron | ENST00000370888 | ENST00000380217 | LRRC1 | chr6 | 53660213 | + | FRY | chr13 | 32705809 | + |
| Frame-shift | ENST00000370882 | ENST00000380250 | LRRC1 | chr6 | 53660213 | + | FRY | chr13 | 32705809 | + |
| 5CDS-intron | ENST00000370882 | ENST00000463566 | LRRC1 | chr6 | 53660213 | + | FRY | chr13 | 32705809 | + |
| 5CDS-intron | ENST00000370882 | ENST00000542859 | LRRC1 | chr6 | 53660213 | + | FRY | chr13 | 32705809 | + |
| 5CDS-intron | ENST00000370882 | ENST00000380217 | LRRC1 | chr6 | 53660213 | + | FRY | chr13 | 32705809 | + |
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FusionProtFeatures for LRRC1_FRY |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRRC1 | FRY |