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Fusion gene ID: 20185 |
FusionGeneSummary for LRPAP1_LRPAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRPAP1_LRPAP1 | Fusion gene ID: 20185 | Hgene | Tgene | Gene symbol | LRPAP1 | LRPAP1 | Gene ID | 4043 | 4043 |
| Gene name | LDL receptor related protein associated protein 1 | LDL receptor related protein associated protein 1 | |
| Synonyms | A2MRAP|A2RAP|HBP44|MRAP|MYP23|RAP|alpha-2-MRAP | A2MRAP|A2RAP|HBP44|MRAP|MYP23|RAP|alpha-2-MRAP | |
| Cytomap | 4p16.3 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | alpha-2-macroglobulin receptor-associated protein39 kDa receptor-associated proteinlow density lipoprotein receptor-related protein associated protein 1low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associa | alpha-2-macroglobulin receptor-associated protein39 kDa receptor-associated proteinlow density lipoprotein receptor-related protein associated protein 1low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associa | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | P30533 | P30533 | |
| Ensembl transtripts involved in fusion gene | ENST00000500728, ENST00000296325, | ENST00000500728, ENST00000296325, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 2 X 2 X 2=8 |
| # samples | 3 | 2 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LRPAP1 [Title/Abstract] AND LRPAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LRPAP1 | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance | 8083232 |
| Hgene | LRPAP1 | GO:0032091 | negative regulation of protein binding | 8083232 |
| Hgene | LRPAP1 | GO:0048259 | regulation of receptor-mediated endocytosis | 7774585 |
| Tgene | LRPAP1 | GO:0010916 | negative regulation of very-low-density lipoprotein particle clearance | 8083232 |
| Tgene | LRPAP1 | GO:0032091 | negative regulation of protein binding | 8083232 |
| Tgene | LRPAP1 | GO:0048259 | regulation of receptor-mediated endocytosis | 7774585 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI470190 | LRPAP1 | chr4 | 3514450 | + | LRPAP1 | chr4 | 3514563 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000500728 | ENST00000500728 | LRPAP1 | chr4 | 3514450 | + | LRPAP1 | chr4 | 3514563 | - |
| intron-intron | ENST00000500728 | ENST00000296325 | LRPAP1 | chr4 | 3514450 | + | LRPAP1 | chr4 | 3514563 | - |
| intron-3UTR | ENST00000296325 | ENST00000500728 | LRPAP1 | chr4 | 3514450 | + | LRPAP1 | chr4 | 3514563 | - |
| intron-intron | ENST00000296325 | ENST00000296325 | LRPAP1 | chr4 | 3514450 | + | LRPAP1 | chr4 | 3514563 | - |
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FusionProtFeatures for LRPAP1_LRPAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRPAP1 | LRPAP1 |