|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 20154 |
FusionGeneSummary for LRP5_CHD6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRP5_CHD6 | Fusion gene ID: 20154 | Hgene | Tgene | Gene symbol | LRP5 | CHD6 | Gene ID | 4041 | 84181 |
| Gene name | LDL receptor related protein 5 | chromodomain helicase DNA binding protein 6 | |
| Synonyms | BMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2 | CHD-6|CHD5|RIGB | |
| Cytomap | 11q13.2 | 20q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7 | chromodomain-helicase-DNA-binding protein 6ATP-dependent helicase CHD6helicase C-terminal domain- and SNF2 N-terminal domain-containing proteinradiation-induced gene B protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | O75197 | Q8TD26 | |
| Ensembl transtripts involved in fusion gene | ENST00000294304, ENST00000529481, | ENST00000373233, ENST00000309279, ENST00000373222, ENST00000480022, | |
| Fusion gene scores | * DoF score | 21 X 16 X 9=3024 | 8 X 9 X 4=288 |
| # samples | 22 | 10 | |
| ** MAII score | log2(22/3024*10)=-3.78088271069641 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LRP5 [Title/Abstract] AND CHD6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LRP5 | GO:0008284 | positive regulation of cell proliferation | 9790987 |
| Hgene | LRP5 | GO:0016055 | Wnt signaling pathway | 17955262 |
| Hgene | LRP5 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification | 11029007 |
| Hgene | LRP5 | GO:0045840 | positive regulation of mitotic nuclear division | 9790987 |
| Hgene | LRP5 | GO:0045893 | positive regulation of transcription, DNA-templated | 15035989|17955262 |
| Hgene | LRP5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12857724 |
| Hgene | LRP5 | GO:0060070 | canonical Wnt signaling pathway | 12121999|12857724|15035989 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-97-A4M3-01A | LRP5 | chr11 | 68131411 | + | CHD6 | chr20 | 40086068 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000294304 | ENST00000373233 | LRP5 | chr11 | 68131411 | + | CHD6 | chr20 | 40086068 | - |
| 5CDS-intron | ENST00000294304 | ENST00000309279 | LRP5 | chr11 | 68131411 | + | CHD6 | chr20 | 40086068 | - |
| 5CDS-intron | ENST00000294304 | ENST00000373222 | LRP5 | chr11 | 68131411 | + | CHD6 | chr20 | 40086068 | - |
| 5CDS-intron | ENST00000294304 | ENST00000480022 | LRP5 | chr11 | 68131411 | + | CHD6 | chr20 | 40086068 | - |
| intron-3CDS | ENST00000529481 | ENST00000373233 | LRP5 | chr11 | 68131411 | + | CHD6 | chr20 | 40086068 | - |
| intron-intron | ENST00000529481 | ENST00000309279 | LRP5 | chr11 | 68131411 | + | CHD6 | chr20 | 40086068 | - |
| intron-intron | ENST00000529481 | ENST00000373222 | LRP5 | chr11 | 68131411 | + | CHD6 | chr20 | 40086068 | - |
| intron-intron | ENST00000529481 | ENST00000480022 | LRP5 | chr11 | 68131411 | + | CHD6 | chr20 | 40086068 | - |
Top |
FusionProtFeatures for LRP5_CHD6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRP5 | CHD6 |