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Fusion gene ID: 20125 |
FusionGeneSummary for LRP1_CAND1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRP1_CAND1 | Fusion gene ID: 20125 | Hgene | Tgene | Gene symbol | LRP1 | CAND1 | Gene ID | 10438 | 55832 |
| Gene name | C1D nuclear receptor corepressor | cullin associated and neddylation dissociated 1 | |
| Synonyms | LRP1|Rrp47|SUN-CoR|SUNCOR|hC1D | TIP120|TIP120A | |
| Cytomap | 2p14 | 12q14.3-q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | nuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressor | cullin-associated NEDD8-dissociated protein 1TBP-interacting protein of 120 kDa Ap120 CAND1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q07954 | Q86VP6 | |
| Ensembl transtripts involved in fusion gene | ENST00000553277, ENST00000243077, ENST00000338962, ENST00000554174, ENST00000553446, | ENST00000545606, ENST00000539109, | |
| Fusion gene scores | * DoF score | 16 X 14 X 7=1568 | 2 X 2 X 2=8 |
| # samples | 17 | 2 | |
| ** MAII score | log2(17/1568*10)=-3.20531890797751 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LRP1 [Title/Abstract] AND CAND1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CAND1 | GO:0010265 | SCF complex assembly | 15537541|21249194 |
| Tgene | CAND1 | GO:0016567 | protein ubiquitination | 12609982|15537541|21249194 |
| Tgene | CAND1 | GO:0030154 | cell differentiation | 10581176 |
| Tgene | CAND1 | GO:0043086 | negative regulation of catalytic activity | 12609982 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A3U6-01A | LRP1 | chr12 | 57596320 | + | CAND1 | chr12 | 67686402 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000553277 | ENST00000545606 | LRP1 | chr12 | 57596320 | + | CAND1 | chr12 | 67686402 | + |
| intron-intron | ENST00000553277 | ENST00000539109 | LRP1 | chr12 | 57596320 | + | CAND1 | chr12 | 67686402 | + |
| Frame-shift | ENST00000243077 | ENST00000545606 | LRP1 | chr12 | 57596320 | + | CAND1 | chr12 | 67686402 | + |
| 5CDS-intron | ENST00000243077 | ENST00000539109 | LRP1 | chr12 | 57596320 | + | CAND1 | chr12 | 67686402 | + |
| intron-3CDS | ENST00000338962 | ENST00000545606 | LRP1 | chr12 | 57596320 | + | CAND1 | chr12 | 67686402 | + |
| intron-intron | ENST00000338962 | ENST00000539109 | LRP1 | chr12 | 57596320 | + | CAND1 | chr12 | 67686402 | + |
| intron-3CDS | ENST00000554174 | ENST00000545606 | LRP1 | chr12 | 57596320 | + | CAND1 | chr12 | 67686402 | + |
| intron-intron | ENST00000554174 | ENST00000539109 | LRP1 | chr12 | 57596320 | + | CAND1 | chr12 | 67686402 | + |
| intron-3CDS | ENST00000553446 | ENST00000545606 | LRP1 | chr12 | 57596320 | + | CAND1 | chr12 | 67686402 | + |
| intron-intron | ENST00000553446 | ENST00000539109 | LRP1 | chr12 | 57596320 | + | CAND1 | chr12 | 67686402 | + |
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FusionProtFeatures for LRP1_CAND1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRP1 | CAND1 |