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Fusion gene ID: 20121 |
FusionGeneSummary for LRP1B_KCNH8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRP1B_KCNH8 | Fusion gene ID: 20121 | Hgene | Tgene | Gene symbol | LRP1B | KCNH8 | Gene ID | 53353 | 131096 |
| Gene name | LDL receptor related protein 1B | potassium voltage-gated channel subfamily H member 8 | |
| Synonyms | LRP-1B|LRP-DIT|LRPDIT | ELK|ELK1|Kv12.1|elk3 | |
| Cytomap | 2q22.1-q22.2 | 3p24.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors) | potassium voltage-gated channel subfamily H member 8ELK channel 3ether-a-go-go-like potassium channel 1ether-a-go-go-like potassium channel 3hElk1potassium channel, voltage gated eag related subfamily H, member 8potassium voltage-gated channel, subf | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NZR2 | Q96L42 | |
| Ensembl transtripts involved in fusion gene | ENST00000389484, ENST00000486364, | ENST00000328405, ENST00000475063, ENST00000537696, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 2 X 2 X 1=4 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: LRP1B [Title/Abstract] AND KCNH8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF364794 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000389484 | ENST00000328405 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
| intron-intron | ENST00000389484 | ENST00000475063 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
| intron-intron | ENST00000389484 | ENST00000537696 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
| intron-intron | ENST00000486364 | ENST00000328405 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
| intron-intron | ENST00000486364 | ENST00000475063 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
| intron-intron | ENST00000486364 | ENST00000537696 | LRP1B | chr2 | 142611154 | + | KCNH8 | chr3 | 19362665 | - |
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FusionProtFeatures for LRP1B_KCNH8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRP1B | KCNH8 |