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Fusion gene ID: 20117 |
FusionGeneSummary for LRP1B_ATP1A3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRP1B_ATP1A3 | Fusion gene ID: 20117 | Hgene | Tgene | Gene symbol | LRP1B | ATP1A3 | Gene ID | 53353 | 478 |
| Gene name | LDL receptor related protein 1B | ATPase Na+/K+ transporting subunit alpha 3 | |
| Synonyms | LRP-1B|LRP-DIT|LRPDIT | AHC2|ATP1A1|CAPOS|DYT12|RDP | |
| Cytomap | 2q22.1-q22.2 | 19q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | low-density lipoprotein receptor-related protein 1BLRP-deleted in tumorslow density lipoprotein receptor related protein-deleted in tumorlow density lipoprotein receptor-related protein 1Blow density lipoprotein-related protein 1B (deleted in tumors) | sodium/potassium-transporting ATPase subunit alpha-3ATPase, Na+/K+ transporting, alpha 3 polypeptideNa(+)/K(+) ATPase alpha(III) subunitNa(+)/K(+) ATPase alpha-3 subunitNa+, K+ activated adenosine triphosphatase alpha subunitNa+/K+ ATPase 3sodium pu | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9NZR2 | P13637 | |
| Ensembl transtripts involved in fusion gene | ENST00000389484, ENST00000486364, | ENST00000302102, ENST00000545399, ENST00000543770, ENST00000602133, ENST00000468774, | |
| Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 3 X 3 X 2=18 |
| # samples | 7 | 3 | |
| ** MAII score | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LRP1B [Title/Abstract] AND ATP1A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATP1A3 | GO:0006883 | cellular sodium ion homeostasis | 10636900 |
| Tgene | ATP1A3 | GO:0010107 | potassium ion import | 10636900 |
| Tgene | ATP1A3 | GO:0030007 | cellular potassium ion homeostasis | 10636900 |
| Tgene | ATP1A3 | GO:0036376 | sodium ion export across plasma membrane | 10636900 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF961292 | LRP1B | chr2 | 142370702 | - | ATP1A3 | chr19 | 42471857 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000389484 | ENST00000302102 | LRP1B | chr2 | 142370702 | - | ATP1A3 | chr19 | 42471857 | + |
| intron-3CDS | ENST00000389484 | ENST00000545399 | LRP1B | chr2 | 142370702 | - | ATP1A3 | chr19 | 42471857 | + |
| intron-3CDS | ENST00000389484 | ENST00000543770 | LRP1B | chr2 | 142370702 | - | ATP1A3 | chr19 | 42471857 | + |
| intron-3CDS | ENST00000389484 | ENST00000602133 | LRP1B | chr2 | 142370702 | - | ATP1A3 | chr19 | 42471857 | + |
| intron-intron | ENST00000389484 | ENST00000468774 | LRP1B | chr2 | 142370702 | - | ATP1A3 | chr19 | 42471857 | + |
| intron-3CDS | ENST00000486364 | ENST00000302102 | LRP1B | chr2 | 142370702 | - | ATP1A3 | chr19 | 42471857 | + |
| intron-3CDS | ENST00000486364 | ENST00000545399 | LRP1B | chr2 | 142370702 | - | ATP1A3 | chr19 | 42471857 | + |
| intron-3CDS | ENST00000486364 | ENST00000543770 | LRP1B | chr2 | 142370702 | - | ATP1A3 | chr19 | 42471857 | + |
| intron-3CDS | ENST00000486364 | ENST00000602133 | LRP1B | chr2 | 142370702 | - | ATP1A3 | chr19 | 42471857 | + |
| intron-intron | ENST00000486364 | ENST00000468774 | LRP1B | chr2 | 142370702 | - | ATP1A3 | chr19 | 42471857 | + |
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FusionProtFeatures for LRP1B_ATP1A3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRP1B | ATP1A3 |