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Fusion gene ID: 20104

FusionGeneSummary for LRP10_MSL1

Fusion gene summary

Fusion gene information	Fusion gene name: LRP10_MSL1
	Fusion gene ID: 20104
		Hgene	Tgene
	Gene symbol	LRP10	MSL1
	Gene ID	26020	339287
	Gene name	LDL receptor related protein 10	male specific lethal 1 homolog
	Synonyms	LRP-10\|LRP9\|MST087\|MSTP087	MSL-1\|hMSL1
	Cytomap	14q11.2	17q21.1
	Type of gene	protein-coding	protein-coding
	Description	low-density lipoprotein receptor-related protein 10	male-specific lethal 1 homologMSL1-like 1male-specific lethal 1-like 1male-specific lethal-1 homolog 1
	Modification date	20180519	20180523
	UniProtAcc	Q7Z4F1	Q68DK7
	Ensembl transtripts involved in fusion gene	ENST00000359591, ENST00000546834, ENST00000470660,	ENST00000398532, ENST00000577454, ENST00000578648, ENST00000579565,
Fusion gene scores	* DoF score	2 X 2 X 2=8	7 X 4 X 4=112
	# samples	2	7
	** MAII score	log2(2/8*10)=1.32192809488736	log2(7/112*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: LRP10 [Title/Abstract] AND MSL1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MSL1	GO:0043984	histone H4-K16 acetylation	20018852

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	LUSC	TCGA-60-2715-01A	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000359591	ENST00000398532	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
In-frame	ENST00000359591	ENST00000577454	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
In-frame	ENST00000359591	ENST00000578648	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
5CDS-5UTR	ENST00000359591	ENST00000579565	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
In-frame	ENST00000546834	ENST00000398532	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
In-frame	ENST00000546834	ENST00000577454	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
In-frame	ENST00000546834	ENST00000578648	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
5CDS-5UTR	ENST00000546834	ENST00000579565	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
3UTR-3CDS	ENST00000470660	ENST00000398532	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
3UTR-3CDS	ENST00000470660	ENST00000577454	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
3UTR-3CDS	ENST00000470660	ENST00000578648	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+
3UTR-5UTR	ENST00000470660	ENST00000579565	LRP10	chr14	23346262	+	MSL1	chr17	38282436	+

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FusionProtFeatures for LRP10_MSL1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LRP10 Q7Z4F1	MSL1 Q68DK7

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Fusion gene ID: 20104

FusionGeneSummary for LRP10_MSL1

FusionProtFeatures for LRP10_MSL1