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Fusion gene ID: 20097 |
FusionGeneSummary for LRIG3_ATF7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRIG3_ATF7 | Fusion gene ID: 20097 | Hgene | Tgene | Gene symbol | LRIG3 | ATF7 | Gene ID | 121227 | 11016 |
| Gene name | leucine rich repeats and immunoglobulin like domains 3 | activating transcription factor 7 | |
| Synonyms | LIG3 | ATFA | |
| Cytomap | 12q14.1 | 12q13.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leucine-rich repeats and immunoglobulin-like domains protein 3LIG-3 | cyclic AMP-dependent transcription factor ATF-7transcription factor ATF-A | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q6UXM1 | P17544 | |
| Ensembl transtripts involved in fusion gene | ENST00000379141, ENST00000320743, | ENST00000548446, ENST00000420353, ENST00000415113, ENST00000456903, ENST00000548118, ENST00000591397, ENST00000328463, ENST00000546661, | |
| Fusion gene scores | * DoF score | 7 X 3 X 4=84 | 8 X 6 X 5=240 |
| # samples | 7 | 10 | |
| ** MAII score | log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LRIG3 [Title/Abstract] AND ATF7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ATF7 | GO:0006355 | regulation of transcription, DNA-templated | 8288576 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PAAD | TCGA-HZ-A49I-01A | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| TCGA | LD | PAAD | TCGA-HZ-A4BK-01A | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000379141 | ENST00000548446 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000379141 | ENST00000420353 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000379141 | ENST00000415113 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000379141 | ENST00000456903 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000379141 | ENST00000548118 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000379141 | ENST00000591397 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000379141 | ENST00000328463 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-intron | ENST00000379141 | ENST00000546661 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000320743 | ENST00000548446 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000320743 | ENST00000420353 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000320743 | ENST00000415113 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000320743 | ENST00000456903 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000320743 | ENST00000548118 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000320743 | ENST00000591397 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-5UTR | ENST00000320743 | ENST00000328463 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
| 5CDS-intron | ENST00000320743 | ENST00000546661 | LRIG3 | chr12 | 59307763 | - | ATF7 | chr12 | 53994805 | - |
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FusionProtFeatures for LRIG3_ATF7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRIG3 | ATF7 |