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Fusion gene ID: 20085 |
FusionGeneSummary for LRCH4_TBC1D1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LRCH4_TBC1D1 | Fusion gene ID: 20085 | Hgene | Tgene | Gene symbol | LRCH4 | TBC1D1 | Gene ID | 4034 | 23216 |
| Gene name | leucine rich repeats and calponin homology domain containing 4 | TBC1 domain family member 1 | |
| Synonyms | LRN|LRRN1|LRRN4|PP14183 | TBC|TBC1 | |
| Cytomap | 7q22.1 | 4p14 | |
| Type of gene | protein-coding | protein-coding | |
| Description | leucine-rich repeat and calponin homology domain-containing protein 4leucine rich repeat neuronal 4leucine-rich neuronal proteinleucine-rich repeats and calponin homology (CH) domain containing 4 | TBC1 domain family member 1TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O75427 | Q86TI0 | |
| Ensembl transtripts involved in fusion gene | ENST00000310300, ENST00000497245, | ENST00000508802, ENST00000261439, ENST00000402522, ENST00000407365, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 8 X 7 X 4=224 |
| # samples | 2 | 9 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LRCH4 [Title/Abstract] AND TBC1D1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE709716 | LRCH4 | chr7 | 100178630 | - | TBC1D1 | chr4 | 38117401 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000310300 | ENST00000508802 | LRCH4 | chr7 | 100178630 | - | TBC1D1 | chr4 | 38117401 | - |
| intron-3CDS | ENST00000310300 | ENST00000261439 | LRCH4 | chr7 | 100178630 | - | TBC1D1 | chr4 | 38117401 | - |
| intron-intron | ENST00000310300 | ENST00000402522 | LRCH4 | chr7 | 100178630 | - | TBC1D1 | chr4 | 38117401 | - |
| intron-3UTR | ENST00000310300 | ENST00000407365 | LRCH4 | chr7 | 100178630 | - | TBC1D1 | chr4 | 38117401 | - |
| intron-3CDS | ENST00000497245 | ENST00000508802 | LRCH4 | chr7 | 100178630 | - | TBC1D1 | chr4 | 38117401 | - |
| intron-3CDS | ENST00000497245 | ENST00000261439 | LRCH4 | chr7 | 100178630 | - | TBC1D1 | chr4 | 38117401 | - |
| intron-intron | ENST00000497245 | ENST00000402522 | LRCH4 | chr7 | 100178630 | - | TBC1D1 | chr4 | 38117401 | - |
| intron-3UTR | ENST00000497245 | ENST00000407365 | LRCH4 | chr7 | 100178630 | - | TBC1D1 | chr4 | 38117401 | - |
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FusionProtFeatures for LRCH4_TBC1D1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LRCH4 | TBC1D1 |