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Fusion gene ID: 20049 |
FusionGeneSummary for LPP_WWTR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LPP_WWTR1 | Fusion gene ID: 20049 | Hgene | Tgene | Gene symbol | LPP | WWTR1 | Gene ID | 4026 | 25937 |
| Gene name | LIM domain containing preferred translocation partner in lipoma | WW domain containing transcription regulator 1 | |
| Synonyms | - | TAZ | |
| Cytomap | 3q27.3-q28 | 3q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lipoma-preferred partnerLIM proteinlipoma preferred partner | WW domain-containing transcription regulator protein 1transcriptional co-activator with PDZ-binding motif | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q93052 | Q9GZV5 | |
| Ensembl transtripts involved in fusion gene | ENST00000448637, ENST00000312675, ENST00000543006, ENST00000471917, | ENST00000465804, ENST00000360632, ENST00000467467, ENST00000474080, | |
| Fusion gene scores | * DoF score | 29 X 22 X 11=7018 | 6 X 4 X 6=144 |
| # samples | 37 | 7 | |
| ** MAII score | log2(37/7018*10)=-4.24546277188585 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LPP [Title/Abstract] AND WWTR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | WWTR1 | GO:0008284 | positive regulation of cell proliferation | 18227151 |
| Tgene | WWTR1 | GO:0010718 | positive regulation of epithelial to mesenchymal transition | 18227151 |
| Tgene | WWTR1 | GO:0017145 | stem cell division | 18568018 |
| Tgene | WWTR1 | GO:0035329 | hippo signaling | 18227151|20412773 |
| Tgene | WWTR1 | GO:0060390 | regulation of SMAD protein signal transduction | 18568018 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-AJ-A3EM-01A | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-5UTR | ENST00000448637 | ENST00000465804 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| intron-intron | ENST00000448637 | ENST00000360632 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| intron-intron | ENST00000448637 | ENST00000467467 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| intron-intron | ENST00000448637 | ENST00000474080 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| 5UTR-5UTR | ENST00000312675 | ENST00000465804 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| 5UTR-intron | ENST00000312675 | ENST00000360632 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| 5UTR-intron | ENST00000312675 | ENST00000467467 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| 5UTR-intron | ENST00000312675 | ENST00000474080 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| 5UTR-5UTR | ENST00000543006 | ENST00000465804 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| 5UTR-intron | ENST00000543006 | ENST00000360632 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| 5UTR-intron | ENST00000543006 | ENST00000467467 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| 5UTR-intron | ENST00000543006 | ENST00000474080 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| intron-5UTR | ENST00000471917 | ENST00000465804 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| intron-intron | ENST00000471917 | ENST00000360632 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| intron-intron | ENST00000471917 | ENST00000467467 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
| intron-intron | ENST00000471917 | ENST00000474080 | LPP | chr3 | 187943315 | + | WWTR1 | chr3 | 149387678 | - |
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FusionProtFeatures for LPP_WWTR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LPP | WWTR1 |