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Fusion gene ID: 20045 |
FusionGeneSummary for LPP_SPATA16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LPP_SPATA16 | Fusion gene ID: 20045 | Hgene | Tgene | Gene symbol | LPP | SPATA16 | Gene ID | 4026 | 83893 |
| Gene name | LIM domain containing preferred translocation partner in lipoma | spermatogenesis associated 16 | |
| Synonyms | - | NYD-SP12|SPGF6 | |
| Cytomap | 3q27.3-q28 | 3q26.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lipoma-preferred partnerLIM proteinlipoma preferred partner | spermatogenesis-associated protein 16testicular tissue protein Li 185testis development protein NYD-SP12testis-specific Golgi protein | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q93052 | Q9BXB7 | |
| Ensembl transtripts involved in fusion gene | ENST00000448637, ENST00000312675, ENST00000543006, ENST00000471917, | ENST00000351008, | |
| Fusion gene scores | * DoF score | 29 X 22 X 11=7018 | 8 X 6 X 6=288 |
| # samples | 37 | 8 | |
| ** MAII score | log2(37/7018*10)=-4.24546277188585 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/288*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LPP [Title/Abstract] AND SPATA16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AQ-A04L-01B | LPP | chr3 | 188584166 | + | SPATA16 | chr3 | 172737365 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000448637 | ENST00000351008 | LPP | chr3 | 188584166 | + | SPATA16 | chr3 | 172737365 | - |
| In-frame | ENST00000312675 | ENST00000351008 | LPP | chr3 | 188584166 | + | SPATA16 | chr3 | 172737365 | - |
| In-frame | ENST00000543006 | ENST00000351008 | LPP | chr3 | 188584166 | + | SPATA16 | chr3 | 172737365 | - |
| intron-3CDS | ENST00000471917 | ENST00000351008 | LPP | chr3 | 188584166 | + | SPATA16 | chr3 | 172737365 | - |
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FusionProtFeatures for LPP_SPATA16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LPP | SPATA16 |