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Fusion gene ID: 20036 |
FusionGeneSummary for LPP_KCNIP4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LPP_KCNIP4 | Fusion gene ID: 20036 | Hgene | Tgene | Gene symbol | LPP | KCNIP4 | Gene ID | 4026 | 80333 |
| Gene name | LIM domain containing preferred translocation partner in lipoma | potassium voltage-gated channel interacting protein 4 | |
| Synonyms | - | CALP|KCHIP4 | |
| Cytomap | 3q27.3-q28 | 4p15.31-p15.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lipoma-preferred partnerLIM proteinlipoma preferred partner | Kv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q93052 | Q6PIL6 | |
| Ensembl transtripts involved in fusion gene | ENST00000448637, ENST00000312675, ENST00000543006, ENST00000471917, | ENST00000382148, ENST00000447367, ENST00000382150, ENST00000382152, ENST00000509207, ENST00000382149, ENST00000359001, | |
| Fusion gene scores | * DoF score | 29 X 22 X 11=7018 | 12 X 7 X 9=756 |
| # samples | 37 | 13 | |
| ** MAII score | log2(37/7018*10)=-4.24546277188585 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/756*10)=-2.53987461119262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LPP [Title/Abstract] AND KCNIP4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-AB2Z-01A | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000448637 | ENST00000382148 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000448637 | ENST00000447367 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000448637 | ENST00000382150 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000448637 | ENST00000382152 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000448637 | ENST00000509207 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000448637 | ENST00000382149 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000448637 | ENST00000359001 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-3CDS | ENST00000312675 | ENST00000382148 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-3CDS | ENST00000312675 | ENST00000447367 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-3CDS | ENST00000312675 | ENST00000382150 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-3CDS | ENST00000312675 | ENST00000382152 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-5UTR | ENST00000312675 | ENST00000509207 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-5UTR | ENST00000312675 | ENST00000382149 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-5UTR | ENST00000312675 | ENST00000359001 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-3CDS | ENST00000543006 | ENST00000382148 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-3CDS | ENST00000543006 | ENST00000447367 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-3CDS | ENST00000543006 | ENST00000382150 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-3CDS | ENST00000543006 | ENST00000382152 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-5UTR | ENST00000543006 | ENST00000509207 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-5UTR | ENST00000543006 | ENST00000382149 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| 5UTR-5UTR | ENST00000543006 | ENST00000359001 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000471917 | ENST00000382148 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000471917 | ENST00000447367 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000471917 | ENST00000382150 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-3CDS | ENST00000471917 | ENST00000382152 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000471917 | ENST00000509207 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000471917 | ENST00000382149 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
| intron-5UTR | ENST00000471917 | ENST00000359001 | LPP | chr3 | 187943315 | + | KCNIP4 | chr4 | 20852290 | - |
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FusionProtFeatures for LPP_KCNIP4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LPP | KCNIP4 |