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Fusion gene ID: 19991 |
FusionGeneSummary for LPCAT2_LPCAT2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LPCAT2_LPCAT2 | Fusion gene ID: 19991 | Hgene | Tgene | Gene symbol | LPCAT2 | LPCAT2 | Gene ID | 54947 | 54947 |
| Gene name | lysophosphatidylcholine acyltransferase 2 | lysophosphatidylcholine acyltransferase 2 | |
| Synonyms | AGPAT11|AYTL1|LysoPAFAT | AGPAT11|AYTL1|LysoPAFAT | |
| Cytomap | 16q12.2 | 16q12.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysophosphatidylcholine acyltransferase 21-AGP acyltransferase 111-AGPAT 111-acylglycerol-3-phosphate O-acyltransferase 111-acylglycerophosphocholine O-acyltransferase1-alkylglycerophosphocholine O-acetyltransferaseLPAAT-alphaLPC acyltransferase 2 | lysophosphatidylcholine acyltransferase 21-AGP acyltransferase 111-AGPAT 111-acylglycerol-3-phosphate O-acyltransferase 111-acylglycerophosphocholine O-acyltransferase1-alkylglycerophosphocholine O-acetyltransferaseLPAAT-alphaLPC acyltransferase 2 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q7L5N7 | Q7L5N7 | |
| Ensembl transtripts involved in fusion gene | ENST00000262134, ENST00000565056, | ENST00000262134, ENST00000565056, | |
| Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 5 X 6 X 3=90 |
| # samples | 5 | 6 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LPCAT2 [Title/Abstract] AND LPCAT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LPCAT2 | GO:0036151 | phosphatidylcholine acyl-chain remodeling | 21498505 |
| Tgene | LPCAT2 | GO:0036151 | phosphatidylcholine acyl-chain remodeling | 21498505 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA602968 | LPCAT2 | chr16 | 55620127 | + | LPCAT2 | chr16 | 55620032 | - | ||
| ChiTaRS3.1 | CN286009 | LPCAT2 | chr16 | 55618722 | - | LPCAT2 | chr16 | 55618734 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000262134 | ENST00000262134 | LPCAT2 | chr16 | 55620127 | + | LPCAT2 | chr16 | 55620032 | - |
| 3UTR-intron | ENST00000262134 | ENST00000565056 | LPCAT2 | chr16 | 55620127 | + | LPCAT2 | chr16 | 55620032 | - |
| intron-3UTR | ENST00000565056 | ENST00000262134 | LPCAT2 | chr16 | 55620127 | + | LPCAT2 | chr16 | 55620032 | - |
| intron-intron | ENST00000565056 | ENST00000565056 | LPCAT2 | chr16 | 55620127 | + | LPCAT2 | chr16 | 55620032 | - |
| 3UTR-3UTR | ENST00000262134 | ENST00000262134 | LPCAT2 | chr16 | 55618722 | - | LPCAT2 | chr16 | 55618734 | + |
| 3UTR-intron | ENST00000262134 | ENST00000565056 | LPCAT2 | chr16 | 55618722 | - | LPCAT2 | chr16 | 55618734 | + |
| intron-3UTR | ENST00000565056 | ENST00000262134 | LPCAT2 | chr16 | 55618722 | - | LPCAT2 | chr16 | 55618734 | + |
| intron-intron | ENST00000565056 | ENST00000565056 | LPCAT2 | chr16 | 55618722 | - | LPCAT2 | chr16 | 55618734 | + |
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FusionProtFeatures for LPCAT2_LPCAT2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LPCAT2 | LPCAT2 |