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Fusion gene ID: 19954

FusionGeneSummary for LONP1_RAD51

Fusion gene summary

Fusion gene information	Fusion gene name: LONP1_RAD51
	Fusion gene ID: 19954
		Hgene	Tgene
	Gene symbol	LONP1	RAD51
	Gene ID	9361	5888
	Gene name	lon peptidase 1, mitochondrial	RAD51 recombinase
	Synonyms	CODASS\|LON\|LONP\|LonHS\|PIM1\|PRSS15\|hLON	BRCC5\|FANCR\|HRAD51\|HsRad51\|HsT16930\|MRMV2\|RAD51A\|RECA
	Cytomap	19p13.3	15q15.1
	Type of gene	protein-coding	protein-coding
	Description	lon protease homolog, mitochondrialhLON ATP-dependent proteaselon protease-like proteinmitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15	DNA repair protein RAD51 homolog 1BRCA1/BRCA2-containing complex, subunit 5RAD51 homolog ARecA, E. coli, homolog ofRecA-like proteinrecombination protein A
	Modification date	20180523	20180527
	UniProtAcc	P36776	Q06609
	Ensembl transtripts involved in fusion gene	ENST00000360614, ENST00000585374, ENST00000593119, ENST00000540670, ENST00000590729, ENST00000590511,	ENST00000423169, ENST00000267868, ENST00000557850, ENST00000532743, ENST00000382643, ENST00000530766,
Fusion gene scores	* DoF score	14 X 10 X 11=1540	3 X 3 X 3=27
	# samples	15	3
	** MAII score	log2(15/1540*10)=-3.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: LONP1 [Title/Abstract] AND RAD51 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	DDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LONP1	GO:0034599	cellular response to oxidative stress	17420247
Hgene	LONP1	GO:0051260	protein homooligomerization	14739292
Hgene	LONP1	GO:0051603	proteolysis involved in cellular protein catabolic process	8248235\|17420247
Tgene	RAD51	GO:0000724	double-strand break repair via homologous recombination	16428451
Tgene	RAD51	GO:0006268	DNA unwinding involved in DNA replication	7988572
Tgene	RAD51	GO:0006974	cellular response to DNA damage stimulus	23509288\|25585578
Tgene	RAD51	GO:0010569	regulation of double-strand break repair via homologous recombination	23754376
Tgene	RAD51	GO:0031297	replication fork processing	25585578
Tgene	RAD51	GO:0051106	positive regulation of DNA ligation	8929543
Tgene	RAD51	GO:0071479	cellular response to ionizing radiation	23509288\|23754376
Tgene	RAD51	GO:0072757	cellular response to camptothecin	23509288

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	CESC	TCGA-EA-A50E-01A	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000360614	ENST00000423169	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
In-frame	ENST00000360614	ENST00000267868	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000360614	ENST00000557850	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000360614	ENST00000532743	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000360614	ENST00000382643	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
5CDS-3UTR	ENST00000360614	ENST00000530766	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000585374	ENST00000423169	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000585374	ENST00000267868	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000585374	ENST00000557850	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000585374	ENST00000532743	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000585374	ENST00000382643	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
5CDS-3UTR	ENST00000585374	ENST00000530766	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000593119	ENST00000423169	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
In-frame	ENST00000593119	ENST00000267868	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000593119	ENST00000557850	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000593119	ENST00000532743	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000593119	ENST00000382643	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
5CDS-3UTR	ENST00000593119	ENST00000530766	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000540670	ENST00000423169	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
In-frame	ENST00000540670	ENST00000267868	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000540670	ENST00000557850	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000540670	ENST00000532743	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000540670	ENST00000382643	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
5CDS-3UTR	ENST00000540670	ENST00000530766	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000590729	ENST00000423169	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
In-frame	ENST00000590729	ENST00000267868	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000590729	ENST00000557850	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000590729	ENST00000532743	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
Frame-shift	ENST00000590729	ENST00000382643	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
5CDS-3UTR	ENST00000590729	ENST00000530766	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
intron-3CDS	ENST00000590511	ENST00000423169	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
intron-3CDS	ENST00000590511	ENST00000267868	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
intron-3CDS	ENST00000590511	ENST00000557850	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
intron-3CDS	ENST00000590511	ENST00000532743	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
intron-3CDS	ENST00000590511	ENST00000382643	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+
intron-3UTR	ENST00000590511	ENST00000530766	LONP1	chr19	5700800	-	RAD51	chr15	41023253	+

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FusionProtFeatures for LONP1_RAD51

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LONP1 P36776	RAD51 Q06609

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Fusion gene ID: 19954

FusionGeneSummary for LONP1_RAD51

FusionProtFeatures for LONP1_RAD51