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Fusion gene ID: 19951 |
FusionGeneSummary for LONP1_FZR1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LONP1_FZR1 | Fusion gene ID: 19951 | Hgene | Tgene | Gene symbol | LONP1 | FZR1 | Gene ID | 9361 | 51343 |
| Gene name | lon peptidase 1, mitochondrial | fizzy and cell division cycle 20 related 1 | |
| Synonyms | CODASS|LON|LONP|LonHS|PIM1|PRSS15|hLON | CDC20C|CDH1|FZR|FZR2|HCDH|HCDH1 | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lon protease homolog, mitochondrialhLON ATP-dependent proteaselon protease-like proteinmitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15 | fizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P36776 | Q9UM11 | |
| Ensembl transtripts involved in fusion gene | ENST00000360614, ENST00000585374, ENST00000593119, ENST00000540670, ENST00000590729, ENST00000590511, | ENST00000441788, ENST00000313639, ENST00000395095, | |
| Fusion gene scores | * DoF score | 14 X 10 X 11=1540 | 5 X 4 X 3=60 |
| # samples | 15 | 5 | |
| ** MAII score | log2(15/1540*10)=-3.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LONP1 [Title/Abstract] AND FZR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LONP1 | GO:0034599 | cellular response to oxidative stress | 17420247 |
| Hgene | LONP1 | GO:0051260 | protein homooligomerization | 14739292 |
| Hgene | LONP1 | GO:0051603 | proteolysis involved in cellular protein catabolic process | 8248235|17420247 |
| Tgene | FZR1 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 18662541|21596315 |
| Tgene | FZR1 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint | 18662541 |
| Tgene | FZR1 | GO:1904668 | positive regulation of ubiquitin protein ligase activity | 11459826 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-SI-A71Q-01A | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000360614 | ENST00000441788 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000360614 | ENST00000313639 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000360614 | ENST00000395095 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-3UTR | ENST00000585374 | ENST00000441788 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000585374 | ENST00000313639 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000585374 | ENST00000395095 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-3UTR | ENST00000593119 | ENST00000441788 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000593119 | ENST00000313639 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000593119 | ENST00000395095 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-3UTR | ENST00000540670 | ENST00000441788 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000540670 | ENST00000313639 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000540670 | ENST00000395095 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-3UTR | ENST00000590729 | ENST00000441788 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000590729 | ENST00000313639 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000590729 | ENST00000395095 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-3UTR | ENST00000590511 | ENST00000441788 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000590511 | ENST00000313639 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
| intron-intron | ENST00000590511 | ENST00000395095 | LONP1 | chr19 | 5694661 | - | FZR1 | chr19 | 3535148 | + |
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FusionProtFeatures for LONP1_FZR1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LONP1 | FZR1 |