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Fusion gene ID: 19946 |
FusionGeneSummary for LONP1_CATSPERD |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LONP1_CATSPERD | Fusion gene ID: 19946 | Hgene | Tgene | Gene symbol | LONP1 | CATSPERD | Gene ID | 9361 | 257062 |
| Gene name | lon peptidase 1, mitochondrial | cation channel sperm associated auxiliary subunit delta | |
| Synonyms | CODASS|LON|LONP|LonHS|PIM1|PRSS15|hLON | TMEM146 | |
| Cytomap | 19p13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lon protease homolog, mitochondrialhLON ATP-dependent proteaselon protease-like proteinmitochondrial ATP-dependent protease Lonmitochondrial lon protease-like proteinserine protease 15 | cation channel sperm-associated protein subunit deltacatSper-deltacatSperdeltacatsper channel auxiliary subunit deltatransmembrane protein 146 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P36776 | Q86XM0 | |
| Ensembl transtripts involved in fusion gene | ENST00000360614, ENST00000585374, ENST00000593119, ENST00000540670, ENST00000590729, ENST00000590511, | ENST00000381614, ENST00000381624, ENST00000309164, | |
| Fusion gene scores | * DoF score | 14 X 10 X 11=1540 | 1 X 1 X 1=1 |
| # samples | 15 | 1 | |
| ** MAII score | log2(15/1540*10)=-3.35989594508638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: LONP1 [Title/Abstract] AND CATSPERD [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LONP1 | GO:0034599 | cellular response to oxidative stress | 17420247 |
| Hgene | LONP1 | GO:0051260 | protein homooligomerization | 14739292 |
| Hgene | LONP1 | GO:0051603 | proteolysis involved in cellular protein catabolic process | 8248235|17420247 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-13-1487-01A | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000360614 | ENST00000381614 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5CDS-5UTR | ENST00000360614 | ENST00000381624 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5CDS-intron | ENST00000360614 | ENST00000309164 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5CDS-5UTR | ENST00000585374 | ENST00000381614 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5CDS-5UTR | ENST00000585374 | ENST00000381624 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5CDS-intron | ENST00000585374 | ENST00000309164 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5CDS-5UTR | ENST00000593119 | ENST00000381614 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5CDS-5UTR | ENST00000593119 | ENST00000381624 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5CDS-intron | ENST00000593119 | ENST00000309164 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| intron-5UTR | ENST00000540670 | ENST00000381614 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| intron-5UTR | ENST00000540670 | ENST00000381624 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| intron-intron | ENST00000540670 | ENST00000309164 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5CDS-5UTR | ENST00000590729 | ENST00000381614 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5CDS-5UTR | ENST00000590729 | ENST00000381624 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5CDS-intron | ENST00000590729 | ENST00000309164 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5UTR-5UTR | ENST00000590511 | ENST00000381614 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5UTR-5UTR | ENST00000590511 | ENST00000381624 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
| 5UTR-intron | ENST00000590511 | ENST00000309164 | LONP1 | chr19 | 5719715 | - | CATSPERD | chr19 | 5727279 | + |
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FusionProtFeatures for LONP1_CATSPERD |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LONP1 | CATSPERD |