|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 19917 |
FusionGeneSummary for LMO7_MUC4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LMO7_MUC4 | Fusion gene ID: 19917 | Hgene | Tgene | Gene symbol | LMO7 | MUC4 | Gene ID | 4008 | 4585 |
| Gene name | LIM domain 7 | mucin 4, cell surface associated | |
| Synonyms | FBX20|FBXO20|LMO7b|LOMP | ASGP|HSA276359|MUC-4 | |
| Cytomap | 13q22.2 | 3q29 | |
| Type of gene | protein-coding | protein-coding | |
| Description | LIM domain only protein 7F-box only protein 20F-box protein Fbx20LIM domain only 7 proteinLMO-7zinc-finger domain-containing protein | mucin-4ascites sialoglycoproteinmucin 4, tracheobronchialpancreatic adenocarcinoma mucintestis mucintracheobronchial mucin | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q8WWI1 | Q99102 | |
| Ensembl transtripts involved in fusion gene | ENST00000341547, ENST00000357063, ENST00000377534, ENST00000321797, ENST00000526202, ENST00000465261, ENST00000605961, | ENST00000346145, ENST00000349607, ENST00000463781, ENST00000475231, ENST00000478685, | |
| Fusion gene scores | * DoF score | 7 X 6 X 4=168 | 5 X 5 X 1=25 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/168*10)=-0.900464326449086 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/25*10)=1.26303440583379 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LMO7 [Title/Abstract] AND MUC4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LMO7 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 17067998 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW391858 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + | ||
| ChiTaRS3.1 | AW391853 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000341547 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000341547 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000341547 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000341547 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000341547 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000357063 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000357063 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000357063 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000357063 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000357063 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| intron-intron | ENST00000377534 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| intron-intron | ENST00000377534 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| intron-intron | ENST00000377534 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| intron-intron | ENST00000377534 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| intron-intron | ENST00000377534 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000321797 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000321797 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000321797 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000321797 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000321797 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000526202 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000526202 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000526202 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000526202 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000526202 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000465261 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000465261 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000465261 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000465261 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| 5CDS-intron | ENST00000465261 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| intron-intron | ENST00000605961 | ENST00000346145 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| intron-intron | ENST00000605961 | ENST00000349607 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| intron-intron | ENST00000605961 | ENST00000463781 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| intron-intron | ENST00000605961 | ENST00000475231 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
| intron-intron | ENST00000605961 | ENST00000478685 | LMO7 | chr13 | 76430648 | - | MUC4 | chr3 | 195530516 | + |
Top |
FusionProtFeatures for LMO7_MUC4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LMO7 | MUC4 |