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Fusion gene ID: 19897

FusionGeneSummary for LMNA_IGFBP2

Fusion gene summary

Fusion gene information	Fusion gene name: LMNA_IGFBP2
	Fusion gene ID: 19897
		Hgene	Tgene
	Gene symbol	LMNA	IGFBP2
	Gene ID	4000	3485
	Gene name	lamin A/C	insulin like growth factor binding protein 2
	Synonyms	CDCD1\|CDDC\|CMD1A\|CMT2B1\|EMD2\|FPL\|FPLD\|FPLD2\|HGPS\|IDC\|LDP1\|LFP\|LGMD1B\|LMN1\|LMNC\|LMNL1\|MADA\|PRO1	IBP2\|IGF-BP53
	Cytomap	1q22	2q35
	Type of gene	protein-coding	protein-coding
	Description	lamin70 kDa laminlamin A/C-like 1mandibuloacral dysplasia type Aprelamin-A/Crenal carcinoma antigen NY-REN-32	insulin-like growth factor-binding protein 2IGF-binding protein 2insulin-like growth factor binding protein 2, 36kDa
	Modification date	20180523	20180523
	UniProtAcc	P02545	P18065
	Ensembl transtripts involved in fusion gene	ENST00000368301, ENST00000361308, ENST00000347559, ENST00000368300, ENST00000368299, ENST00000448611, ENST00000368297, ENST00000473598, ENST00000392353, ENST00000496738,	ENST00000233809, ENST00000456764,
Fusion gene scores	* DoF score	11 X 12 X 6=792	2 X 2 X 2=8
	# samples	14	2
	** MAII score	log2(14/792*10)=-2.50007360313464 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: LMNA [Title/Abstract] AND IGFBP2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LMNA	GO:0090343	positive regulation of cell aging	20458013
Tgene	IGFBP2	GO:0042104	positive regulation of activated T cell proliferation	15694994

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	UCEC	TCGA-EO-A3AY-01A	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-3CDS	ENST00000368301	ENST00000233809	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000368301	ENST00000456764	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000361308	ENST00000233809	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000361308	ENST00000456764	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
3UTR-3CDS	ENST00000347559	ENST00000233809	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
3UTR-3CDS	ENST00000347559	ENST00000456764	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
3UTR-3CDS	ENST00000368300	ENST00000233809	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
3UTR-3CDS	ENST00000368300	ENST00000456764	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
In-frame	ENST00000368299	ENST00000233809	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
In-frame	ENST00000368299	ENST00000456764	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000448611	ENST00000233809	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000448611	ENST00000456764	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000368297	ENST00000233809	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000368297	ENST00000456764	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000473598	ENST00000233809	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000473598	ENST00000456764	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000392353	ENST00000233809	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000392353	ENST00000456764	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000496738	ENST00000233809	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+
intron-3CDS	ENST00000496738	ENST00000456764	LMNA	chr1	156109108	+	IGFBP2	chr2	217525456	+

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FusionProtFeatures for LMNA_IGFBP2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LMNA P02545	IGFBP2 P18065

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Fusion gene ID: 19897

FusionGeneSummary for LMNA_IGFBP2

FusionProtFeatures for LMNA_IGFBP2