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Fusion gene ID: 19884 |
FusionGeneSummary for LMBRD2_ERG |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LMBRD2_ERG | Fusion gene ID: 19884 | Hgene | Tgene | Gene symbol | LMBRD2 | ERG | Gene ID | 92255 | 2078 |
| Gene name | LMBR1 domain containing 2 | ERG, ETS transcription factor | |
| Synonyms | - | erg-3|p55 | |
| Cytomap | 5p13.2 | 21q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | LMBR1 domain-containing protein 2 | transcriptional regulator ERGFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian erythroblastosis virus E26 on | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q68DH5 | P11308 | |
| Ensembl transtripts involved in fusion gene | ENST00000296603, | ENST00000398907, ENST00000398905, ENST00000288319, ENST00000398897, ENST00000398911, ENST00000398910, ENST00000417133, ENST00000442448, ENST00000453032, ENST00000398919, ENST00000429727, ENST00000485493, | |
| Fusion gene scores | * DoF score | 5 X 3 X 4=60 | 13 X 15 X 8=1560 |
| # samples | 5 | 226 | |
| ** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(226/1560*10)=0.53477674355294 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LMBRD2 [Title/Abstract] AND ERG [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ERG | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18195090|23913826 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LGG | TCGA-DU-6406-01A | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000296603 | ENST00000398907 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| 5CDS-3UTR | ENST00000296603 | ENST00000398905 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| 5CDS-3UTR | ENST00000296603 | ENST00000288319 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| 5CDS-3UTR | ENST00000296603 | ENST00000398897 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| 5CDS-3UTR | ENST00000296603 | ENST00000398911 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| 5CDS-3UTR | ENST00000296603 | ENST00000398910 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| 5CDS-3UTR | ENST00000296603 | ENST00000417133 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| 5CDS-3UTR | ENST00000296603 | ENST00000442448 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| 5CDS-intron | ENST00000296603 | ENST00000453032 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| 5CDS-intron | ENST00000296603 | ENST00000398919 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| 5CDS-intron | ENST00000296603 | ENST00000429727 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
| 5CDS-intron | ENST00000296603 | ENST00000485493 | LMBRD2 | chr5 | 36108636 | - | ERG | chr21 | 39752323 | - |
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FusionProtFeatures for LMBRD2_ERG |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LMBRD2 | ERG |