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Fusion gene ID: 19865 |
FusionGeneSummary for LMAN2_SPOCK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LMAN2_SPOCK1 | Fusion gene ID: 19865 | Hgene | Tgene | Gene symbol | LMAN2 | SPOCK1 | Gene ID | 10960 | 6695 |
| Gene name | lectin, mannose binding 2 | SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 | |
| Synonyms | C5orf8|GP36B|VIP36 | SPOCK|TESTICAN|TIC1 | |
| Cytomap | 5q35.3 | 5q31.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | vesicular integral-membrane protein VIP36glycoprotein GP36bvesicular integral protein of 36 kDavesicular integral-membrane protein 36 | testican-1SPARC/osteonectin, cwcv and kazal like domains proteoglycan 1sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q12907 | Q08629 | |
| Ensembl transtripts involved in fusion gene | ENST00000303127, ENST00000515209, ENST00000506310, | ENST00000394945, ENST00000282223, ENST00000509978, | |
| Fusion gene scores | * DoF score | 7 X 3 X 7=147 | 4 X 4 X 2=32 |
| # samples | 7 | 4 | |
| ** MAII score | log2(7/147*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LMAN2 [Title/Abstract] AND SPOCK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SPOCK1 | GO:0010812 | negative regulation of cell-substrate adhesion | 12853036 |
| Tgene | SPOCK1 | GO:0010951 | negative regulation of endopeptidase activity | 14511383 |
| Tgene | SPOCK1 | GO:0010977 | negative regulation of neuron projection development | 12853036 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-BP-4986-01A | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000303127 | ENST00000394945 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
| Frame-shift | ENST00000303127 | ENST00000282223 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
| 5CDS-intron | ENST00000303127 | ENST00000509978 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
| Frame-shift | ENST00000515209 | ENST00000394945 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
| Frame-shift | ENST00000515209 | ENST00000282223 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
| 5CDS-intron | ENST00000515209 | ENST00000509978 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
| intron-3CDS | ENST00000506310 | ENST00000394945 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
| intron-3CDS | ENST00000506310 | ENST00000282223 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
| intron-intron | ENST00000506310 | ENST00000509978 | LMAN2 | chr5 | 176761285 | - | SPOCK1 | chr5 | 136448250 | - |
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FusionProtFeatures for LMAN2_SPOCK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LMAN2 | SPOCK1 |