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Fusion gene ID: 19750 |
FusionGeneSummary for LIN54_GDE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LIN54_GDE1 | Fusion gene ID: 19750 | Hgene | Tgene | Gene symbol | LIN54 | GDE1 | Gene ID | 132660 | 51573 |
| Gene name | lin-54 DREAM MuvB core complex component | glycerophosphodiester phosphodiesterase 1 | |
| Synonyms | CXCDC1|JC8.6|MIP120|TCX1 | 363E6.2|MIR16 | |
| Cytomap | 4q21.22 | 16p12.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein lin-54 homologCXC domain-containing protein 1lin-54 homolog | glycerophosphodiester phosphodiesterase 1RGS16-interacting membrane proteinmembrane interacting protein of RGS16 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q6MZP7 | Q9NZC3 | |
| Ensembl transtripts involved in fusion gene | ENST00000395282, ENST00000395283, ENST00000340417, ENST00000442461, ENST00000446851, ENST00000510557, ENST00000506560, ENST00000505397, ENST00000505905, | ENST00000353258, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 3 X 1=12 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: LIN54 [Title/Abstract] AND GDE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW881269 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000395282 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000395283 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000340417 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000442461 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000446851 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000510557 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000506560 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000505397 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
| intron-3UTR | ENST00000505905 | ENST00000353258 | LIN54 | chr4 | 83893284 | - | GDE1 | chr16 | 19513902 | - |
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FusionProtFeatures for LIN54_GDE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LIN54 | GDE1 |