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Fusion gene ID: 1968 |
FusionGeneSummary for ANTXR1_NCOA3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANTXR1_NCOA3 | Fusion gene ID: 1968 | Hgene | Tgene | Gene symbol | ANTXR1 | NCOA3 | Gene ID | 84168 | 8202 |
| Gene name | ANTXR cell adhesion molecule 1 | nuclear receptor coactivator 3 | |
| Synonyms | ATR|GAPO|TEM8 | ACTR|AIB-1|AIB1|CAGH16|CTG26|KAT13B|RAC3|SRC-3|SRC3|TNRC14|TNRC16|TRAM-1|bHLHe42|pCIP | |
| Cytomap | 2p13.3 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | anthrax toxin receptor 12310008J16Rik2810405N18Riktumor endothelial marker 8 | nuclear receptor coactivator 3CBP-interacting proteinamplified in breast cancer 1 proteinclass E basic helix-loop-helix protein 42receptor-associated coactivator 3steroid receptor coactivator protein 3thyroid hormone receptor activator molecule 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H6X2 | Q9Y6Q9 | |
| Ensembl transtripts involved in fusion gene | ENST00000303714, ENST00000409829, ENST00000409349, | ENST00000341724, ENST00000372004, ENST00000371998, ENST00000371997, ENST00000497292, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 9 X 6 X 4=216 |
| # samples | 2 | 9 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(9/216*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ANTXR1 [Title/Abstract] AND NCOA3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ANTXR1 | GO:0031532 | actin cytoskeleton reorganization | 16762926 |
| Hgene | ANTXR1 | GO:0034446 | substrate adhesion-dependent cell spreading | 16762926 |
| Tgene | NCOA3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9267036 |
| Tgene | NCOA3 | GO:0071392 | cellular response to estradiol stimulus | 15831516 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF839348 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000303714 | ENST00000341724 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| 5CDS-intron | ENST00000303714 | ENST00000372004 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| 5CDS-intron | ENST00000303714 | ENST00000371998 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| 5CDS-intron | ENST00000303714 | ENST00000371997 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| 5CDS-intron | ENST00000303714 | ENST00000497292 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| intron-intron | ENST00000409829 | ENST00000341724 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| intron-intron | ENST00000409829 | ENST00000372004 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| intron-intron | ENST00000409829 | ENST00000371998 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| intron-intron | ENST00000409829 | ENST00000371997 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| intron-intron | ENST00000409829 | ENST00000497292 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| 5CDS-intron | ENST00000409349 | ENST00000341724 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| 5CDS-intron | ENST00000409349 | ENST00000372004 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| 5CDS-intron | ENST00000409349 | ENST00000371998 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| 5CDS-intron | ENST00000409349 | ENST00000371997 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
| 5CDS-intron | ENST00000409349 | ENST00000497292 | ANTXR1 | chr2 | 69397409 | + | NCOA3 | chr20 | 46219171 | + |
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FusionProtFeatures for ANTXR1_NCOA3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANTXR1 | NCOA3 |