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Fusion gene ID: 19659 |
FusionGeneSummary for LGALS9_LGALS9B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LGALS9_LGALS9B | Fusion gene ID: 19659 | Hgene | Tgene | Gene symbol | LGALS9 | LGALS9B | Gene ID | 3965 | 284194 |
| Gene name | galectin 9 | galectin 9B | |
| Synonyms | HUAT|LGALS9A | - | |
| Cytomap | 17q11.2 | 17p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | galectin-9ecalectingal-9lectin, galactoside-binding, soluble, 9tumor antigen HOM-HD-21urate transporter/channel protein | galectin-9Bgal-9Bgalectin-9 likegalectin-9 pseudogenegalectin-9-like protein Alectin, galactoside-binding, soluble, 9B | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | O00182 | Q3B8N2 | |
| Ensembl transtripts involved in fusion gene | ENST00000310394, ENST00000395473, ENST00000302228, ENST00000313648, ENST00000413914, ENST00000448970, | ENST00000423676, ENST00000324290, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 2 X 2 X 2=8 |
| # samples | 1 | 2 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: LGALS9 [Title/Abstract] AND LGALS9B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LGALS9 | GO:0006954 | inflammatory response | 23817958 |
| Hgene | LGALS9 | GO:0007565 | female pregnancy | 23242525 |
| Hgene | LGALS9 | GO:0010628 | positive regulation of gene expression | 16116184 |
| Hgene | LGALS9 | GO:0010629 | negative regulation of gene expression | 23408620 |
| Hgene | LGALS9 | GO:0032673 | regulation of interleukin-4 production | 16116184 |
| Hgene | LGALS9 | GO:0032674 | regulation of interleukin-5 production | 16116184 |
| Hgene | LGALS9 | GO:0032689 | negative regulation of interferon-gamma production | 23408620 |
| Hgene | LGALS9 | GO:0032753 | positive regulation of interleukin-4 production | 20209097 |
| Hgene | LGALS9 | GO:0032834 | positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response | 20209097 |
| Hgene | LGALS9 | GO:0034134 | toll-like receptor 2 signaling pathway | 16116184 |
| Hgene | LGALS9 | GO:0034142 | toll-like receptor 4 signaling pathway | 16116184 |
| Hgene | LGALS9 | GO:0038066 | p38MAPK cascade | 16116184 |
| Hgene | LGALS9 | GO:0045953 | negative regulation of natural killer cell mediated cytotoxicity | 23408620 |
| Hgene | LGALS9 | GO:0046598 | positive regulation of viral entry into host cell | 21670307 |
| Hgene | LGALS9 | GO:0050718 | positive regulation of interleukin-1 beta secretion | 20209097 |
| Hgene | LGALS9 | GO:0060135 | maternal process involved in female pregnancy | 25578313 |
| Hgene | LGALS9 | GO:0070241 | positive regulation of activated T cell autonomous cell death | 20209097 |
| Hgene | LGALS9 | GO:0070371 | ERK1 and ERK2 cascade | 16116184 |
| Hgene | LGALS9 | GO:0070555 | response to interleukin-1 | 23817958 |
| Hgene | LGALS9 | GO:0071346 | cellular response to interferon-gamma | 23817958 |
| Hgene | LGALS9 | GO:0071636 | positive regulation of transforming growth factor beta production | 20209097 |
| Hgene | LGALS9 | GO:1902715 | positive regulation of interferon-gamma secretion | 20209097 |
| Hgene | LGALS9 | GO:1904469 | positive regulation of tumor necrosis factor secretion | 20209097 |
| Hgene | LGALS9 | GO:2000562 | negative regulation of CD4-positive, alpha-beta T cell proliferation | 20209097 |
| Hgene | LGALS9 | GO:2000563 | positive regulation of CD4-positive, alpha-beta T cell proliferation | 16116184 |
| Hgene | LGALS9 | GO:2000667 | positive regulation of interleukin-13 secretion | 20209097 |
| Hgene | LGALS9 | GO:2000670 | positive regulation of dendritic cell apoptotic process | 16116184 |
| Hgene | LGALS9 | GO:2001181 | positive regulation of interleukin-10 secretion | 16116184|20209097 |
| Hgene | LGALS9 | GO:2001190 | positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell | 16116184 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG980811 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000310394 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000310394 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000395473 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000395473 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000302228 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000302228 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| In-frame | ENST00000313648 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| In-frame | ENST00000313648 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000413914 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| Frame-shift | ENST00000413914 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| intron-3CDS | ENST00000448970 | ENST00000423676 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
| intron-3CDS | ENST00000448970 | ENST00000324290 | LGALS9 | chr17 | 25975890 | + | LGALS9B | chr17 | 20355127 | + |
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FusionProtFeatures for LGALS9_LGALS9B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LGALS9 | LGALS9B |