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Fusion gene ID: 19657

FusionGeneSummary for LGALS8_TRIM67

Fusion gene summary

Fusion gene information	Fusion gene name: LGALS8_TRIM67
	Fusion gene ID: 19657
		Hgene	Tgene
	Gene symbol	LGALS8	TRIM67
	Gene ID	3964	440730
	Gene name	galectin 8	tripartite motif containing 67
	Synonyms	Gal-8\|PCTA-1\|PCTA1\|Po66-CBP	TNL
	Cytomap	1q43	1q42.2
	Type of gene	protein-coding	protein-coding
	Description	galectin-8Po66 carbohydrate binding proteingalectin-8glectin, galactoside-binding, soluble, 8po66 carbohydrate-binding proteinprostate carcinoma tumor antigen 1	tripartite motif-containing protein 67TRIM9-like protein TNL
	Modification date	20180519	20180522
	UniProtAcc	O00214	Q6ZTA4
	Ensembl transtripts involved in fusion gene	ENST00000526589, ENST00000527974, ENST00000352231, ENST00000341872, ENST00000450372, ENST00000366584, ENST00000416919, ENST00000323938, ENST00000526634, ENST00000525042,	ENST00000444294, ENST00000366652, ENST00000449018, ENST00000366653,
Fusion gene scores	* DoF score	5 X 5 X 3=75	2 X 3 X 3=18
	# samples	7	3
	** MAII score	log2(7/75*10)=-0.0995356735509144 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: LGALS8 [Title/Abstract] AND TRIM67 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LGALS8	GO:1904977	lymphatic endothelial cell migration	19268462

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	BRCA	TCGA-E2-A15M-01A	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000526589	ENST00000444294	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000526589	ENST00000366652	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000526589	ENST00000449018	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000526589	ENST00000366653	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000527974	ENST00000444294	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000527974	ENST00000366652	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000527974	ENST00000449018	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000527974	ENST00000366653	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000352231	ENST00000444294	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000352231	ENST00000366652	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000352231	ENST00000449018	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000352231	ENST00000366653	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000341872	ENST00000444294	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000341872	ENST00000366652	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000341872	ENST00000449018	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000341872	ENST00000366653	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000450372	ENST00000444294	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000450372	ENST00000366652	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000450372	ENST00000449018	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000450372	ENST00000366653	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000366584	ENST00000444294	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000366584	ENST00000366652	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000366584	ENST00000449018	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000366584	ENST00000366653	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000416919	ENST00000444294	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000416919	ENST00000366652	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000416919	ENST00000449018	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000416919	ENST00000366653	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000323938	ENST00000444294	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000323938	ENST00000366652	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000323938	ENST00000449018	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000323938	ENST00000366653	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000526634	ENST00000444294	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000526634	ENST00000366652	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000526634	ENST00000449018	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000526634	ENST00000366653	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000525042	ENST00000444294	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000525042	ENST00000366652	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000525042	ENST00000449018	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+
In-frame	ENST00000525042	ENST00000366653	LGALS8	chr1	236689415	+	TRIM67	chr1	231333117	+

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FusionProtFeatures for LGALS8_TRIM67

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LGALS8 O00214	TRIM67 Q6ZTA4

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Fusion gene ID: 19657

FusionGeneSummary for LGALS8_TRIM67

FusionProtFeatures for LGALS8_TRIM67