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Fusion gene ID: 19633 |
FusionGeneSummary for LETM1_NELFA |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LETM1_NELFA | Fusion gene ID: 19633 | Hgene | Tgene | Gene symbol | LETM1 | NELFA | Gene ID | 3954 | 7469 |
| Gene name | leucine zipper and EF-hand containing transmembrane protein 1 | negative elongation factor complex member A | |
| Synonyms | SLC55A1 | NELF-A|P/OKcl.15|WHSC2 | |
| Cytomap | 4p16.3 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mitochondrial proton/calcium exchanger proteinLETM1 and EF-hand domain-containing protein 1, mitochondrialMdm38 homologleucine zipper-EF-hand containing transmembrane protein 1 | negative elongation factor Awolf-Hirschhorn syndrome candidate 2 protein | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O95202 | Q9H3P2 | |
| Ensembl transtripts involved in fusion gene | ENST00000302787, ENST00000512189, | ENST00000382882, ENST00000411638, ENST00000542778, | |
| Fusion gene scores | * DoF score | 5 X 5 X 4=100 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: LETM1 [Title/Abstract] AND NELFA [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LETM1 | GO:0006851 | mitochondrial calcium ion transmembrane transport | 19797662 |
| Hgene | LETM1 | GO:0051560 | mitochondrial calcium ion homeostasis | 19797662 |
| Hgene | LETM1 | GO:0099093 | calcium export from the mitochondrion | 19797662 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCEC | TCGA-PG-A914-01A | LETM1 | chr4 | 1823908 | - | NELFA | chr4 | 2025263 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000302787 | ENST00000382882 | LETM1 | chr4 | 1823908 | - | NELFA | chr4 | 2025263 | - |
| 5CDS-intron | ENST00000302787 | ENST00000411638 | LETM1 | chr4 | 1823908 | - | NELFA | chr4 | 2025263 | - |
| 5CDS-intron | ENST00000302787 | ENST00000542778 | LETM1 | chr4 | 1823908 | - | NELFA | chr4 | 2025263 | - |
| intron-intron | ENST00000512189 | ENST00000382882 | LETM1 | chr4 | 1823908 | - | NELFA | chr4 | 2025263 | - |
| intron-intron | ENST00000512189 | ENST00000411638 | LETM1 | chr4 | 1823908 | - | NELFA | chr4 | 2025263 | - |
| intron-intron | ENST00000512189 | ENST00000542778 | LETM1 | chr4 | 1823908 | - | NELFA | chr4 | 2025263 | - |
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FusionProtFeatures for LETM1_NELFA |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LETM1 | NELFA |