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Fusion gene ID: 19553 |
FusionGeneSummary for LDHA_PLA2G2A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LDHA_PLA2G2A | Fusion gene ID: 19553 | Hgene | Tgene | Gene symbol | LDHA | PLA2G2A | Gene ID | 3939 | 5320 |
| Gene name | lactate dehydrogenase A | phospholipase A2 group IIA | |
| Synonyms | GSD11|HEL-S-133P|LDHM|PIG19 | MOM1|PLA2|PLA2B|PLA2L|PLA2S|PLAS1|sPLA2 | |
| Cytomap | 11p15.1 | 1p36.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | L-lactate dehydrogenase A chainLDH muscle subunitLDH-ALDH-Mcell proliferation-inducing gene 19 proteinepididymis secretory sperm binding protein Li 133Plactate dehydrogenase Mproliferation-inducing gene 19renal carcinoma antigen NY-REN-59 | phospholipase A2, membrane associatedGIIC sPLA2NPS-PLA2group IIA phospholipase A2non-pancreatic secretory phospholipase A2phosphatidylcholine 2-acylhydrolase 2Aphospholipase A2, group IIA (platelets, synovial fluid) | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P00338 | P14555 | |
| Ensembl transtripts involved in fusion gene | ENST00000422447, ENST00000430553, ENST00000396222, ENST00000227157, ENST00000540430, ENST00000379412, ENST00000542179, | ENST00000400520, ENST00000496748, ENST00000375111, | |
| Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 6 X 3 X 5=90 |
| # samples | 8 | 6 | |
| ** MAII score | log2(8/50*10)=0.678071905112638 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LDHA [Title/Abstract] AND PLA2G2A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | PLA2G2A | GO:0006644 | phospholipid metabolic process | 17069818 |
| Tgene | PLA2G2A | GO:0046473 | phosphatidic acid metabolic process | 9032461 |
| Tgene | PLA2G2A | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22837859 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-HC-7744-01A | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000422447 | ENST00000400520 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000422447 | ENST00000496748 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000422447 | ENST00000375111 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000430553 | ENST00000400520 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000430553 | ENST00000496748 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000430553 | ENST00000375111 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| intron-5UTR | ENST00000396222 | ENST00000400520 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| intron-5UTR | ENST00000396222 | ENST00000496748 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| intron-5UTR | ENST00000396222 | ENST00000375111 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000227157 | ENST00000400520 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000227157 | ENST00000496748 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000227157 | ENST00000375111 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000540430 | ENST00000400520 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000540430 | ENST00000496748 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000540430 | ENST00000375111 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000379412 | ENST00000400520 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000379412 | ENST00000496748 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000379412 | ENST00000375111 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000542179 | ENST00000400520 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000542179 | ENST00000496748 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
| 5CDS-5UTR | ENST00000542179 | ENST00000375111 | LDHA | chr11 | 18425358 | + | PLA2G2A | chr1 | 20305372 | - |
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FusionProtFeatures for LDHA_PLA2G2A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LDHA | PLA2G2A |