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Fusion gene ID: 19523 |
FusionGeneSummary for LCN1_LYZ |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LCN1_LYZ | Fusion gene ID: 19523 | Hgene | Tgene | Gene symbol | LCN1 | LYZ | Gene ID | 3933 | 4069 |
| Gene name | lipocalin 1 | lysozyme | |
| Synonyms | PMFA|TLC|TP|VEGP | LYZF1|LZM | |
| Cytomap | 9q34.3 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lipocalin-1VEG proteinVon Ebner gland proteinprotein migrating faster than albumintear prealbumin | lysozyme C1,4-beta-N-acetylmuramidase Cc-type lysozymelysozyme F1 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P31025 | P61626 | |
| Ensembl transtripts involved in fusion gene | ENST00000263598, ENST00000371781, | ENST00000261267, ENST00000549690, ENST00000548839, | |
| Fusion gene scores | * DoF score | 3 X 3 X 1=9 | 26 X 11 X 9=2574 |
| # samples | 3 | 30 | |
| ** MAII score | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(30/2574*10)=-3.10097764772482 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LCN1 [Title/Abstract] AND LYZ [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LYZ | GO:0031640 | killing of cells of other organism | 9727055 |
| Tgene | LYZ | GO:0042742 | defense response to bacterium | 21093056 |
| Tgene | LYZ | GO:0050830 | defense response to Gram-positive bacterium | 21093056 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CK429413 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000263598 | ENST00000261267 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| 5CDS-intron | ENST00000263598 | ENST00000549690 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| 5CDS-intron | ENST00000263598 | ENST00000548839 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| Frame-shift | ENST00000371781 | ENST00000261267 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| 5CDS-intron | ENST00000371781 | ENST00000549690 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
| 5CDS-intron | ENST00000371781 | ENST00000548839 | LCN1 | chr9 | 138414015 | + | LYZ | chr12 | 69746005 | + |
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FusionProtFeatures for LCN1_LYZ |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LCN1 | LYZ |