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Fusion gene ID: 19515 |
FusionGeneSummary for LBX2-AS1_IFITM2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LBX2-AS1_IFITM2 | Fusion gene ID: 19515 | Hgene | Tgene | Gene symbol | LBX2-AS1 | IFITM2 | Gene ID | 151534 | 10581 |
| Gene name | LBX2 antisense RNA 1 | interferon induced transmembrane protein 2 | |
| Synonyms | - | 1-8D|DSPA2c | |
| Cytomap | 2p13.1 | 11p15.5 | |
| Type of gene | ncRNA | protein-coding | |
| Description | LBX2 antisense RNA 1 (non-protein coding) | interferon-induced transmembrane protein 2dispanin subfamily A member 2cinterferon-inducible protein 1-8D | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | Q01629 | ||
| Ensembl transtripts involved in fusion gene | ENST00000603175, ENST00000548978, | ENST00000533141, ENST00000399817, ENST00000602569, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 5 X 3=75 |
| # samples | 1 | 5 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LBX2-AS1 [Title/Abstract] AND IFITM2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | IFITM2 | GO:0009615 | response to virus | 20943977|21253575|22479637 |
| Tgene | IFITM2 | GO:0034341 | response to interferon-gamma | 21253575 |
| Tgene | IFITM2 | GO:0035455 | response to interferon-alpha | 22479637 |
| Tgene | IFITM2 | GO:0035456 | response to interferon-beta | 21253575 |
| Tgene | IFITM2 | GO:0045071 | negative regulation of viral genome replication | 21253575 |
| Tgene | IFITM2 | GO:0046597 | negative regulation of viral entry into host cell | 21253575|23358889 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AI082075 | LBX2-AS1 | chr2 | 74732253 | + | IFITM2 | chr11 | 309308 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000603175 | ENST00000533141 | LBX2-AS1 | chr2 | 74732253 | + | IFITM2 | chr11 | 309308 | - |
| intron-3UTR | ENST00000603175 | ENST00000399817 | LBX2-AS1 | chr2 | 74732253 | + | IFITM2 | chr11 | 309308 | - |
| intron-3UTR | ENST00000603175 | ENST00000602569 | LBX2-AS1 | chr2 | 74732253 | + | IFITM2 | chr11 | 309308 | - |
| intron-intron | ENST00000548978 | ENST00000533141 | LBX2-AS1 | chr2 | 74732253 | + | IFITM2 | chr11 | 309308 | - |
| intron-3UTR | ENST00000548978 | ENST00000399817 | LBX2-AS1 | chr2 | 74732253 | + | IFITM2 | chr11 | 309308 | - |
| intron-3UTR | ENST00000548978 | ENST00000602569 | LBX2-AS1 | chr2 | 74732253 | + | IFITM2 | chr11 | 309308 | - |
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FusionProtFeatures for LBX2-AS1_IFITM2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LBX2-AS1 | IFITM2 |