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Fusion gene ID: 19514 |
FusionGeneSummary for LBX1-AS1_RBFOX2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: LBX1-AS1_RBFOX2 | Fusion gene ID: 19514 | Hgene | Tgene | Gene symbol | LBX1-AS1 | RBFOX2 | Gene ID | 399806 | 23543 |
| Gene name | LBX1 antisense RNA 1 | RNA binding fox-1 homolog 2 | |
| Synonyms | MUSE | FOX2|Fox-2|HNRBP2|HRNBP2|RBM9|RTA|dJ106I20.3|fxh | |
| Cytomap | 10q24.32 | 22q12.3 | |
| Type of gene | ncRNA | protein-coding | |
| Description | LBX1 antisense RNA 1 (head to head) | RNA binding protein fox-1 homolog 2RNA binding protein, fox-1 homolog 2RNA-binding motif protein 9fox-1 homolog Bfox-1 homologuehexaribonucleotide-binding protein 2repressor of tamoxifen transcriptional activity | |
| Modification date | 20180329 | 20180523 | |
| UniProtAcc | O43251 | ||
| Ensembl transtripts involved in fusion gene | ENST00000434878, ENST00000547077, ENST00000546988, ENST00000454527, ENST00000430651, ENST00000456391, | ENST00000405409, ENST00000414461, ENST00000449924, ENST00000262829, ENST00000397303, ENST00000359369, ENST00000416721, ENST00000438146, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 9 X 9 X 4=324 |
| # samples | 1 | 10 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(10/324*10)=-1.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: LBX1-AS1 [Title/Abstract] AND RBFOX2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RBFOX2 | GO:0030520 | intracellular estrogen receptor signaling pathway | 11875103 |
| Tgene | RBFOX2 | GO:0045892 | negative regulation of transcription, DNA-templated | 11875103 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AK026741 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000434878 | ENST00000405409 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000434878 | ENST00000414461 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000434878 | ENST00000449924 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000434878 | ENST00000262829 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000434878 | ENST00000397303 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000434878 | ENST00000359369 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000434878 | ENST00000416721 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000434878 | ENST00000438146 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000547077 | ENST00000405409 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000547077 | ENST00000414461 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000547077 | ENST00000449924 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000547077 | ENST00000262829 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000547077 | ENST00000397303 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000547077 | ENST00000359369 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000547077 | ENST00000416721 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000547077 | ENST00000438146 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000546988 | ENST00000405409 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000546988 | ENST00000414461 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000546988 | ENST00000449924 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000546988 | ENST00000262829 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000546988 | ENST00000397303 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000546988 | ENST00000359369 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000546988 | ENST00000416721 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000546988 | ENST00000438146 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000454527 | ENST00000405409 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000454527 | ENST00000414461 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000454527 | ENST00000449924 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000454527 | ENST00000262829 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000454527 | ENST00000397303 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000454527 | ENST00000359369 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000454527 | ENST00000416721 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000454527 | ENST00000438146 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000430651 | ENST00000405409 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000430651 | ENST00000414461 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000430651 | ENST00000449924 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000430651 | ENST00000262829 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000430651 | ENST00000397303 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000430651 | ENST00000359369 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000430651 | ENST00000416721 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000430651 | ENST00000438146 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000456391 | ENST00000405409 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000456391 | ENST00000414461 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000456391 | ENST00000449924 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000456391 | ENST00000262829 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000456391 | ENST00000397303 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000456391 | ENST00000359369 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000456391 | ENST00000416721 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
| intron-intron | ENST00000456391 | ENST00000438146 | LBX1-AS1 | chr10 | 102994678 | + | RBFOX2 | chr22 | 36234748 | - |
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FusionProtFeatures for LBX1-AS1_RBFOX2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LBX1-AS1 | RBFOX2 |