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Fusion gene ID: 19501 |
FusionGeneSummary for LASP1_RBX1 |
Fusion gene summary |
Fusion gene information | Fusion gene name: LASP1_RBX1 | Fusion gene ID: 19501 | Hgene | Tgene | Gene symbol | LASP1 | RBX1 | Gene ID | 3927 | 9978 |
Gene name | LIM and SH3 protein 1 | ring-box 1 | |
Synonyms | Lasp-1|MLN50 | BA554C12.1|RNF75|ROC1 | |
Cytomap | 17q12 | 22q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | LIM and SH3 domain protein 1metastatic lymph node gene 50 protein | E3 ubiquitin-protein ligase RBX1E3 ubiquitin-protein transferase RBX1RING finger protein 75RING-box protein 1ZYP proteinregulator of cullins 1ring-box 1, E3 ubiquitin protein ligase | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | Q14847 | P62877 | |
Ensembl transtripts involved in fusion gene | ENST00000318008, ENST00000433206, ENST00000435347, | ENST00000216225, | |
Fusion gene scores | * DoF score | 9 X 9 X 4=324 | 6 X 4 X 5=120 |
# samples | 11 | 6 | |
** MAII score | log2(11/324*10)=-1.55849028935997 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: LASP1 [Title/Abstract] AND RBX1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | RBX1 | GO:0006513 | protein monoubiquitination | 22358839 |
Tgene | RBX1 | GO:0016567 | protein ubiquitination | 15103331|17543862|20389280 |
Tgene | RBX1 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 15103331 |
Tgene | RBX1 | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process | 20389280 |
Tgene | RBX1 | GO:0045116 | protein neddylation | 19250909 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PAAD | TCGA-FB-AAQ3-01A | LASP1 | chr17 | 37046757 | + | RBX1 | chr22 | 41349559 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000318008 | ENST00000216225 | LASP1 | chr17 | 37046757 | + | RBX1 | chr22 | 41349559 | + |
intron-3CDS | ENST00000433206 | ENST00000216225 | LASP1 | chr17 | 37046757 | + | RBX1 | chr22 | 41349559 | + |
In-frame | ENST00000435347 | ENST00000216225 | LASP1 | chr17 | 37046757 | + | RBX1 | chr22 | 41349559 | + |
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FusionProtFeatures for LASP1_RBX1 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
LASP1 | RBX1 |
Plays an important role in the regulation of dynamicactin-based, cytoskeletal activities. Agonist-dependent changes inLASP1 phosphorylation may also serve to regulate actin-associatedion transport activities, not only in the parietal cell but alsoin certain other F-actin-rich secretory epithelial cell types (Bysimilarity). {ECO:0000250}. | E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediatethe ubiquitination and subsequent proteasomal degradation oftarget proteins, including proteins involved in cell cycleprogression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1collaborate in tandem to mediate ubiquitination of targetproteins, ARIH1 mediating addition of the first ubiquitin on CRLstargets (PubMed:27565346). The functional specificity of the E3ubiquitin-protein ligase complexes depends on the variablesubstrate recognition components. As a component of the CSAcomplex promotes the ubiquitination of ERCC6 resulting inproteasomal degradation. Through the RING-type zinc finger, seemsto recruit the E2 ubiquitination enzyme, like CDC34, to thecomplex and brings it into close proximity to the substrate.Probably also stimulates CDC34 autoubiquitination. May be requiredfor histone H3 and histone H4 ubiquitination in response toultraviolet and for subsequent DNA repair. Promotes theneddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction withUBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41.In concert with ATF2 and CUL3, promotes degradation of KAT5thereby attenuating its ability to acetylate and activate ATM.{ECO:0000269|PubMed:10579999, ECO:0000269|PubMed:11027288,ECO:0000269|PubMed:15983046, ECO:0000269|PubMed:16678110,ECO:0000269|PubMed:16751180, ECO:0000269|PubMed:18397884,ECO:0000269|PubMed:19112177, ECO:0000269|PubMed:19679664,ECO:0000269|PubMed:23455478, ECO:0000269|PubMed:27565346,ECO:0000269|PubMed:29769719}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | LASP1 | chr17:37046757 | chr22:41349559 | ENST00000318008 | + | 3 | 7 | 5_56 | 83 | 262 | Domain | LIM zinc-binding |
Hgene | LASP1 | chr17:37046757 | chr22:41349559 | ENST00000435347 | + | 3 | 8 | 5_56 | 83 | 708 | Domain | LIM zinc-binding |
Tgene | >RBX1 | chr17:37046757 | chr22:41349559 | ENST00000216225 | + | 0 | 5 | 53_98 | 26 | 109 | Zinc finger | RING-type |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >LASP1 | chr17:37046757 | chr22:41349559 | ENST00000318008 | + | 3 | 7 | 201_204 | 83 | 262 | Compositional bias | Note=Poly-Gly |
Hgene | >LASP1 | chr17:37046757 | chr22:41349559 | ENST00000435347 | + | 3 | 8 | 201_204 | 83 | 708 | Compositional bias | Note=Poly-Gly |
Hgene | >LASP1 | chr17:37046757 | chr22:41349559 | ENST00000318008 | + | 3 | 7 | 202_261 | 83 | 262 | Domain | SH3 |
Hgene | >LASP1 | chr17:37046757 | chr22:41349559 | ENST00000435347 | + | 3 | 8 | 202_261 | 83 | 708 | Domain | SH3 |
Hgene | >LASP1 | chr17:37046757 | chr22:41349559 | ENST00000318008 | + | 3 | 7 | 61_95 | 83 | 262 | Repeat | Note=Nebulin 1 |
Hgene | >LASP1 | chr17:37046757 | chr22:41349559 | ENST00000318008 | + | 3 | 7 | 97_131 | 83 | 262 | Repeat | Note=Nebulin 2 |
Hgene | >LASP1 | chr17:37046757 | chr22:41349559 | ENST00000435347 | + | 3 | 8 | 61_95 | 83 | 708 | Repeat | Note=Nebulin 1 |
Hgene | >LASP1 | chr17:37046757 | chr22:41349559 | ENST00000435347 | + | 3 | 8 | 97_131 | 83 | 708 | Repeat | Note=Nebulin 2 |
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FusionGeneSequence for LASP1_RBX1 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_LASP1_ENST00000318008_chr17_37046757_+_RBX1_ENST00000216225_chr22_41349559_+_166aa MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQWNAVALW >In-frame_LASP1_ENST00000435347_chr17_37046757_+_RBX1_ENST00000216225_chr22_41349559_+_166aa MNPNCARCGKIVYPTEKVNCLDKFWHKACFHCETCKMTLNMKNYKGYEKKPYCNAHYPKQSFTMVADTPENLRLKQQSELQSQWNAVALW |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_LASP1_ENST00000318008_chr17_37046757_+_RBX1_ENST00000216225_chr22_41349559_+_498nt ATGAACCCCAACTGCGCCCGGTGCGGCAAGATCGTGTATCCCACGGAGAAGGTGAACTGTCTGGATAAGTTCTGGCATAAAGCATGCTTC CATTGCGAGACCTGCAAGATGACACTGAACATGAAGAACTACAAGGGCTACGAGAAGAAGCCCTACTGCAACGCACACTACCCCAAGCAG TCCTTCACCATGGTGGCGGACACCCCGGAAAACCTTCGCCTCAAGCAACAGAGTGAGCTCCAGAGTCAGTGGAATGCAGTAGCCCTCTGG GCCTGGGATATTGTGGTTGATAACTGTGCCATCTGCAGGAACCACATTATGGATCTTTGCATAGAATGTCAAGCTAACCAGGCGTCCGCT ACTTCAGAAGAGTGTACTGTCGCATGGGGAGTCTGTAACCATGCTTTTCACTTCCACTGCATCTCTCGCTGGCTCAAAACACGACAGGTG >In-frame_LASP1_ENST00000435347_chr17_37046757_+_RBX1_ENST00000216225_chr22_41349559_+_498nt ATGAACCCCAACTGCGCCCGGTGCGGCAAGATCGTGTATCCCACGGAGAAGGTGAACTGTCTGGATAAGTTCTGGCATAAAGCATGCTTC CATTGCGAGACCTGCAAGATGACACTGAACATGAAGAACTACAAGGGCTACGAGAAGAAGCCCTACTGCAACGCACACTACCCCAAGCAG TCCTTCACCATGGTGGCGGACACCCCGGAAAACCTTCGCCTCAAGCAACAGAGTGAGCTCCAGAGTCAGTGGAATGCAGTAGCCCTCTGG GCCTGGGATATTGTGGTTGATAACTGTGCCATCTGCAGGAACCACATTATGGATCTTTGCATAGAATGTCAAGCTAACCAGGCGTCCGCT ACTTCAGAAGAGTGTACTGTCGCATGGGGAGTCTGTAACCATGCTTTTCACTTCCACTGCATCTCTCGCTGGCTCAAAACACGACAGGTG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_LASP1_ENST00000318008_chr17_37046757_+_RBX1_ENST00000216225_chr22_41349559_+_1650nt GCAGTCAGCCTGAGAGCGCTGAGGCGCCAGCACCGCGGGCCCCGCCGTCCCCCCAGGAACCCGCCCCCGCGCAGCCCCACGTCGCCCGGA GAGCGCGCCTCGCTGCGCGTGCCCTTGCCCGCGCCCGAGGCGCGTGCCCGCCCCAGTGCAGCCCCTCCTCCCCGCTGTGTTTATTAGGGG AAGGAGGGCGGAGGCGGAGGCCAGTTCCCCAGCTCCAGCCGCCGTCGCTGCTGCCTGTGTAGTTGCAGCCGCGGCCGCCTCCCGCCAGCT CGCCTCGGGGAACAGGACGCGCGTGAGCTCAGGCGTCCCCGCCCCAGCTTTTCTCGGAACCATGAACCCCAACTGCGCCCGGTGCGGCAA GATCGTGTATCCCACGGAGAAGGTGAACTGTCTGGATAAGTTCTGGCATAAAGCATGCTTCCATTGCGAGACCTGCAAGATGACACTGAA CATGAAGAACTACAAGGGCTACGAGAAGAAGCCCTACTGCAACGCACACTACCCCAAGCAGTCCTTCACCATGGTGGCGGACACCCCGGA AAACCTTCGCCTCAAGCAACAGAGTGAGCTCCAGAGTCAGTGGAATGCAGTAGCCCTCTGGGCCTGGGATATTGTGGTTGATAACTGTGC CATCTGCAGGAACCACATTATGGATCTTTGCATAGAATGTCAAGCTAACCAGGCGTCCGCTACTTCAGAAGAGTGTACTGTCGCATGGGG AGTCTGTAACCATGCTTTTCACTTCCACTGCATCTCTCGCTGGCTCAAAACACGACAGGTGTGTCCATTGGACAACAGAGAGTGGGAATT CCAAAAGTATGGGCACTAGGAAAAGACTTCTTCCATCAAGCTTAATTGTTTTGTTATTCATTTAATGACTTTCCCTGCTGTTACCTAATT ACAAATTGGATGGAACTGTGTTTTTTTCTGCTTTGTTTTTTCAGTTTGCTGTTTCTGTAGCCATATTGTATTCTGTGTCAAATAAAGTCC AGTTGGATTCTGGAACGGATGCTCTCTCTTGTGTATGTGAACAAAGTGAACATAAATGAAGAGTCTCCCCTTCCAAGGCTGAAAACTCAG CTTTTGAAAGTGAAATGTTTGTTCATCGGGGCCAGAGCAGGGTTGTCCTCTGAGCGCATCACTTAGTGACGAGGAATCCAACAGCTCAAG GCAGAGTGTGGATCACCGGCTCCCGAAAACAGCAGTCAGCCCTTCTTTCTCCTGTGTGACAGCAGTGGGCAGCTGAAAGAGGGAAGAATG TGGGATTCAGTCATCAAACCCAGTTCTGAGTCCTGGTTCCACAGCTTGGGTACTGATGGCAATCTTGGCCAAGTTGTCTCTCTACTCTGA ACTTTCCTCCTCTGTACTGTGGGCTTCTGAGGACTAAGTGGCATCATGTGGGCACAGAGAGAAGCTTTGTAAAATGTAAAACCGCTATAC AAATGTGACCTTTGGTTGTGTATGACAGCAGTCCCCAACCTTTTTGCCACCAGGGATTGGTTTCATGGAAGACGATTTTTCCATGGACCG GGGGTGGGGCGGGGGTGTGCTTGGGGATGGTTTTGGAACTGTTCCACCTGAGATCATGAGGCAGTAGATGGACCGCGCAACCTAGATCCC >In-frame_LASP1_ENST00000435347_chr17_37046757_+_RBX1_ENST00000216225_chr22_41349559_+_1366nt GGACGCGCGTGAGCTCAGGCGTCCCCGCCCCAGCTTTTCTCGGAACCATGAACCCCAACTGCGCCCGGTGCGGCAAGATCGTGTATCCCA CGGAGAAGGTGAACTGTCTGGATAAGTTCTGGCATAAAGCATGCTTCCATTGCGAGACCTGCAAGATGACACTGAACATGAAGAACTACA AGGGCTACGAGAAGAAGCCCTACTGCAACGCACACTACCCCAAGCAGTCCTTCACCATGGTGGCGGACACCCCGGAAAACCTTCGCCTCA AGCAACAGAGTGAGCTCCAGAGTCAGTGGAATGCAGTAGCCCTCTGGGCCTGGGATATTGTGGTTGATAACTGTGCCATCTGCAGGAACC ACATTATGGATCTTTGCATAGAATGTCAAGCTAACCAGGCGTCCGCTACTTCAGAAGAGTGTACTGTCGCATGGGGAGTCTGTAACCATG CTTTTCACTTCCACTGCATCTCTCGCTGGCTCAAAACACGACAGGTGTGTCCATTGGACAACAGAGAGTGGGAATTCCAAAAGTATGGGC ACTAGGAAAAGACTTCTTCCATCAAGCTTAATTGTTTTGTTATTCATTTAATGACTTTCCCTGCTGTTACCTAATTACAAATTGGATGGA ACTGTGTTTTTTTCTGCTTTGTTTTTTCAGTTTGCTGTTTCTGTAGCCATATTGTATTCTGTGTCAAATAAAGTCCAGTTGGATTCTGGA ACGGATGCTCTCTCTTGTGTATGTGAACAAAGTGAACATAAATGAAGAGTCTCCCCTTCCAAGGCTGAAAACTCAGCTTTTGAAAGTGAA ATGTTTGTTCATCGGGGCCAGAGCAGGGTTGTCCTCTGAGCGCATCACTTAGTGACGAGGAATCCAACAGCTCAAGGCAGAGTGTGGATC ACCGGCTCCCGAAAACAGCAGTCAGCCCTTCTTTCTCCTGTGTGACAGCAGTGGGCAGCTGAAAGAGGGAAGAATGTGGGATTCAGTCAT CAAACCCAGTTCTGAGTCCTGGTTCCACAGCTTGGGTACTGATGGCAATCTTGGCCAAGTTGTCTCTCTACTCTGAACTTTCCTCCTCTG TACTGTGGGCTTCTGAGGACTAAGTGGCATCATGTGGGCACAGAGAGAAGCTTTGTAAAATGTAAAACCGCTATACAAATGTGACCTTTG GTTGTGTATGACAGCAGTCCCCAACCTTTTTGCCACCAGGGATTGGTTTCATGGAAGACGATTTTTCCATGGACCGGGGGTGGGGCGGGG GTGTGCTTGGGGATGGTTTTGGAACTGTTCCACCTGAGATCATGAGGCAGTAGATGGACCGCGCAACCTAGATCCCTCACATGCACGGTT |
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FusionGenePPI for LASP1_RBX1 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
LASP1 | TRIP13, PLSCR1, FHL3, MDFI, ZYX, TERF1, TINF2, ACD, POT1, ATXN1, FN1, DAZAP2, CD81, GOLGA2, PSMA3, REL, TRIM27, TCF4, FXR2, SPRY2, ARHGEF15, ZC2HC1A, THAP1, SEPT3, LZTS2, RHOXF2, KRTAP4-2, ZBTB9, ZDHHC17, CCDC8, ILK, HAX1, DNAAF2, THAP8, FYTTD1, NFYA, OR10H3, RDH12, SLC25A32, SLC25A44, C11orf65, TAS2R41, AHNAK, ARFGAP1, DDB1, EIF4B, HSPB1, HSPE1, LGALS1, MAP4, NXF1, CRK, STAT3, SH2D2A, CEP170, FBF1, SCLT1, DCTN1, U2AF2, CDH1, ZNF764, SNRNP27, PGK1, EZR, SPTAN1, NCL, UHRF1, NAT10, PDIA5, API5, KRT18, KRT2, G3BP2, AP3M1, NCOR2, CDK12, MYO1C, ACTR3, CLTC, DNMT1, EHMT2, SNAI1, HIST1H3A, TRIM25, TES | RBX1 | VHL, DET1, RFWD2, SKP1, CAND1, CUL1, CCND1, CCND2, CCND3, CUL7, CUL2, CUL4A, CUL4B, NEDD8, CUL3, HSPA8, FBXO3, FBXO22, TUBA1B, ACTG1, HSPA1A, FBXW8, CDC34, FBXO18, DCUN1D1, SKP2, CUL5, ABTB2, RPS6KB1, PTGS2, FBXO11, PGAM5, PSMA6, DDB1, DDB2, FBXO31, ZC3HC1, KEAP1, GAN, ENC1, KLHL41, DIO2, ARID1B, TCEB2, SMAD3, FBXW11, CASP3, ING3, VPRBP, CORO7, UBXN7, TRPC4AP, FBXO42, CRBN, RICTOR, CSNK1E, MAPK8IP2, MAP3K7, TAB1, FRZB, ZAK, RAG1, MED8, TCEB1, HOXB4, GLMN, ELAVL1, MCM10, PRAME, BTRC, FBXW7, CUL9, FBXW2, FBXL5, FBXO2, FBXO6, FBXO44, FBXO17, FBXO27, PSMA2, KLHL7, ERCC8, FBXO25, CCNF, FBXL12, PML, HINT1, GRK5, MKNK2, UBE2D1, LRR1, LRRC14, DDA1, COPS3, COPS4, COPS6, COPS5, COPS7A, UBE2D3, UBE2D2, UBE2M, UBE2G1, MYB, APP, SESN2, SESN1, KLHL3, UBE2G2, FEM1B, HIF1A, UBE2R2, FBXL15, UBE2L3, TRIM27, RNF126, TRIM74, HAX1, SERTAD1, OS9, RHOBTB3, DCUN1D5, GFPT1, HIST1H4A, MTSS1, VRK2, NEDD4, MAP4K1, DCUN1D3, DAB2IP, TP53, UBE2L6, ESR1, IP6K1, GPS1, UBE2E3, RBX1, HIST1H1A, HIST1H1C, CDKN1B, SAMHD1, EEF1A1, HSPB1, KBTBD6, KBTBD7, FBXO21, IBTK, EZH2, GATA2, GHR, MAGEC2, KDM2B, RHOB, CREB3L3, DCUN1D2, DCUN1D4, KCTD17, DTL, UBE2E2, UVRAG, FBXO7, KLHL18, AIRE, FBXO32, ERBB2IP |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for LASP1_RBX1 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for LASP1_RBX1 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | LASP1 | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | LASP1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | RBX1 | C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |