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Fusion gene ID: 1944 |
FusionGeneSummary for ANO6_PRKAB2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANO6_PRKAB2 | Fusion gene ID: 1944 | Hgene | Tgene | Gene symbol | ANO6 | PRKAB2 | Gene ID | 196527 | 5565 |
| Gene name | anoctamin 6 | protein kinase AMP-activated non-catalytic subunit beta 2 | |
| Synonyms | BDPLT7|SCTS|TMEM16F | - | |
| Cytomap | 12q12 | 1q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | anoctamin-6SCAN channelsmall-conductance calcium-activated nonselective cation channeltransmembrane protein 16F | 5'-AMP-activated protein kinase subunit beta-25'-AMP-activated protein kinase, beta-2 subunitAMP-activated protein kinase beta 2 non-catalytic subunitAMPK beta 2AMPK beta-2 chainAMPK subunit beta-2protein kinase, AMP-activated, beta 2 non-catalytic | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q4KMQ2 | O43741 | |
| Ensembl transtripts involved in fusion gene | ENST00000426898, ENST00000425752, ENST00000423947, ENST00000435642, ENST00000320560, ENST00000441606, | ENST00000254101, ENST00000496858, ENST00000425272, | |
| Fusion gene scores | * DoF score | 9 X 8 X 6=432 | 2 X 2 X 1=4 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/432*10)=-2.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: ANO6 [Title/Abstract] AND PRKAB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ANO6 | GO:0006812 | cation transport | 22946059 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA836812 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000426898 | ENST00000254101 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| intron-intron | ENST00000426898 | ENST00000496858 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| intron-intron | ENST00000426898 | ENST00000425272 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| intron-3UTR | ENST00000425752 | ENST00000254101 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| intron-intron | ENST00000425752 | ENST00000496858 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| intron-intron | ENST00000425752 | ENST00000425272 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| intron-3UTR | ENST00000423947 | ENST00000254101 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| intron-intron | ENST00000423947 | ENST00000496858 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| intron-intron | ENST00000423947 | ENST00000425272 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| intron-3UTR | ENST00000435642 | ENST00000254101 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| intron-intron | ENST00000435642 | ENST00000496858 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| intron-intron | ENST00000435642 | ENST00000425272 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| 3UTR-3UTR | ENST00000320560 | ENST00000254101 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| 3UTR-intron | ENST00000320560 | ENST00000496858 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| 3UTR-intron | ENST00000320560 | ENST00000425272 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| 3UTR-3UTR | ENST00000441606 | ENST00000254101 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| 3UTR-intron | ENST00000441606 | ENST00000496858 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
| 3UTR-intron | ENST00000441606 | ENST00000425272 | ANO6 | chr12 | 45825749 | - | PRKAB2 | chr1 | 146626712 | + |
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FusionProtFeatures for ANO6_PRKAB2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANO6 | PRKAB2 |