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Fusion gene ID: 19259 |
FusionGeneSummary for KRT1_ANKS1A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KRT1_ANKS1A | Fusion gene ID: 19259 | Hgene | Tgene | Gene symbol | KRT1 | ANKS1A | Gene ID | 3848 | 23294 |
| Gene name | keratin 1 | ankyrin repeat and sterile alpha motif domain containing 1A | |
| Synonyms | CK1|EHK|EHK1|EPPK|K1|KRT1A|NEPPK | ANKS1 | |
| Cytomap | 12q13.13 | 6p21.31 | |
| Type of gene | protein-coding | protein-coding | |
| Description | keratin, type II cytoskeletal 167 kDa cytokeratinCK-1cytokeratin 1epidermolytic hyperkeratosis 1hair alpha proteinkeratin 1, type IItype-II keratin Kb1 | ankyrin repeat and SAM domain-containing protein 1AOdinankyrin repeat and SAM domain containing 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P04264 | Q92625 | |
| Ensembl transtripts involved in fusion gene | ENST00000252244, | ENST00000360359, ENST00000535627, ENST00000470698, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 26 X 6 X 14=2184 |
| # samples | 2 | 28 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(28/2184*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KRT1 [Title/Abstract] AND ANKS1A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KRT1 | GO:0018149 | peptide cross-linking | 7543090 |
| Hgene | KRT1 | GO:0051290 | protein heterotetramerization | 27595935 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CV-6954-01A | KRT1 | chr12 | 53068520 | - | ANKS1A | chr6 | 34977682 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000252244 | ENST00000360359 | KRT1 | chr12 | 53068520 | - | ANKS1A | chr6 | 34977682 | + |
| 5CDS-intron | ENST00000252244 | ENST00000535627 | KRT1 | chr12 | 53068520 | - | ANKS1A | chr6 | 34977682 | + |
| 5CDS-intron | ENST00000252244 | ENST00000470698 | KRT1 | chr12 | 53068520 | - | ANKS1A | chr6 | 34977682 | + |
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FusionProtFeatures for KRT1_ANKS1A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KRT1 | ANKS1A |