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Fusion gene ID: 19214

FusionGeneSummary for KRI1_DNM2

Fusion gene summary

Fusion gene information	Fusion gene name: KRI1_DNM2
	Fusion gene ID: 19214
		Hgene	Tgene
	Gene symbol	KRI1	DNM2
	Gene ID	65095	1785
	Gene name	KRI1 homolog	dynamin 2
	Synonyms	-	CMT2M\|CMTDI1\|CMTDIB\|DI-CMTB\|DYN2\|DYNII\|LCCS5
	Cytomap	19p13.2	19p13.2
	Type of gene	protein-coding	protein-coding
	Description	protein KRI1 homolog	dynamin-2dynamin II
	Modification date	20180523	20180527
	UniProtAcc	Q8N9T8	P50570
	Ensembl transtripts involved in fusion gene	ENST00000312962, ENST00000361821, ENST00000537964,	ENST00000585892, ENST00000314646, ENST00000359692, ENST00000389253, ENST00000355667, ENST00000408974, ENST00000591819,
Fusion gene scores	* DoF score	5 X 5 X 3=75	10 X 9 X 10=900
	# samples	12	13
	** MAII score	log2(12/75*10)=0.678071905112638 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(13/900*10)=-2.79141337818858 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: KRI1 [Title/Abstract] AND DNM2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DNM2	GO:1903526	negative regulation of membrane tubulation	18388313

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	OV	TCGA-25-1626-01A	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000312962	ENST00000585892	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
In-frame	ENST00000312962	ENST00000314646	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
In-frame	ENST00000312962	ENST00000359692	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
In-frame	ENST00000312962	ENST00000389253	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
In-frame	ENST00000312962	ENST00000355667	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
In-frame	ENST00000312962	ENST00000408974	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
5CDS-intron	ENST00000312962	ENST00000591819	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
In-frame	ENST00000361821	ENST00000585892	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
In-frame	ENST00000361821	ENST00000314646	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
In-frame	ENST00000361821	ENST00000359692	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
In-frame	ENST00000361821	ENST00000389253	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
In-frame	ENST00000361821	ENST00000355667	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
In-frame	ENST00000361821	ENST00000408974	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
5CDS-intron	ENST00000361821	ENST00000591819	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
5UTR-3CDS	ENST00000537964	ENST00000585892	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
5UTR-3CDS	ENST00000537964	ENST00000314646	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
5UTR-3CDS	ENST00000537964	ENST00000359692	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
5UTR-3CDS	ENST00000537964	ENST00000389253	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
5UTR-3CDS	ENST00000537964	ENST00000355667	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
5UTR-3CDS	ENST00000537964	ENST00000408974	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+
5UTR-intron	ENST00000537964	ENST00000591819	KRI1	chr19	10672343	-	DNM2	chr19	10916592	+

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FusionProtFeatures for KRI1_DNM2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KRI1 Q8N9T8	DNM2 P50570

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Fusion gene ID: 19214

FusionGeneSummary for KRI1_DNM2

FusionProtFeatures for KRI1_DNM2