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Fusion gene ID: 19179 |
FusionGeneSummary for KPNA4_LIG1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KPNA4_LIG1 | Fusion gene ID: 19179 | Hgene | Tgene | Gene symbol | KPNA4 | LIG1 | Gene ID | 3840 | 26018 |
| Gene name | karyopherin subunit alpha 4 | leucine rich repeats and immunoglobulin like domains 1 | |
| Synonyms | IPOA3|QIP1|SRP3 | LIG-1|LIG1 | |
| Cytomap | 3q25.33 | 3p14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | importin subunit alpha-3importin alpha Q1importin subunit alpha-4karyopherin alpha 4 (importin alpha 3) | leucine-rich repeats and immunoglobulin-like domains protein 1leucine-rich repeat protein LRIG1ortholog of mouse integral membrane glycoprotein LIG-1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O00629 | P18858 | |
| Ensembl transtripts involved in fusion gene | ENST00000334256, ENST00000469804, | ENST00000263274, ENST00000536218, ENST00000427526, ENST00000599165, | |
| Fusion gene scores | * DoF score | 8 X 6 X 6=288 | 6 X 6 X 4=144 |
| # samples | 10 | 6 | |
| ** MAII score | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KPNA4 [Title/Abstract] AND LIG1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW391238 | KPNA4 | chr3 | 160214275 | + | LIG1 | chr19 | 48623781 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000334256 | ENST00000263274 | KPNA4 | chr3 | 160214275 | + | LIG1 | chr19 | 48623781 | + |
| intron-intron | ENST00000334256 | ENST00000536218 | KPNA4 | chr3 | 160214275 | + | LIG1 | chr19 | 48623781 | + |
| intron-intron | ENST00000334256 | ENST00000427526 | KPNA4 | chr3 | 160214275 | + | LIG1 | chr19 | 48623781 | + |
| intron-intron | ENST00000334256 | ENST00000599165 | KPNA4 | chr3 | 160214275 | + | LIG1 | chr19 | 48623781 | + |
| intron-intron | ENST00000469804 | ENST00000263274 | KPNA4 | chr3 | 160214275 | + | LIG1 | chr19 | 48623781 | + |
| intron-intron | ENST00000469804 | ENST00000536218 | KPNA4 | chr3 | 160214275 | + | LIG1 | chr19 | 48623781 | + |
| intron-intron | ENST00000469804 | ENST00000427526 | KPNA4 | chr3 | 160214275 | + | LIG1 | chr19 | 48623781 | + |
| intron-intron | ENST00000469804 | ENST00000599165 | KPNA4 | chr3 | 160214275 | + | LIG1 | chr19 | 48623781 | + |
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FusionProtFeatures for KPNA4_LIG1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KPNA4 | LIG1 |