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Fusion gene ID: 19166 |
FusionGeneSummary for KPNA1_NCK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KPNA1_NCK1 | Fusion gene ID: 19166 | Hgene | Tgene | Gene symbol | KPNA1 | NCK1 | Gene ID | 3836 | 4690 |
| Gene name | karyopherin subunit alpha 1 | NCK adaptor protein 1 | |
| Synonyms | IPOA5|NPI-1|RCH2|SRP1 | NCK|NCKalpha|nck-1 | |
| Cytomap | 3q21.1 | 3q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | importin subunit alpha-5RAG cohort protein 2SRP1-betaimportin alpha 5importin subunit alpha-1importin-alpha-S1karyopherin alpha 1 (importin alpha 5)nucleoprotein interactor 1recombination activating gene cohort 2 | cytoplasmic protein NCK1NCK tyrosine kinaseSH2/SH3 adaptor protein NCK-alphamelanoma NCK proteinnon-catalytic region of tyrosine kinase | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P52294 | P16333 | |
| Ensembl transtripts involved in fusion gene | ENST00000344337, ENST00000466923, | ENST00000288986, ENST00000481752, ENST00000469404, | |
| Fusion gene scores | * DoF score | 7 X 4 X 7=196 | 6 X 3 X 5=90 |
| # samples | 7 | 6 | |
| ** MAII score | log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: KPNA1 [Title/Abstract] AND NCK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NCK1 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation | 14676213|16835242 |
| Tgene | NCK1 | GO:0036493 | positive regulation of translation in response to endoplasmic reticulum stress | 14676213 |
| Tgene | NCK1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 10026169 |
| Tgene | NCK1 | GO:0060548 | negative regulation of cell death | 18835251 |
| Tgene | NCK1 | GO:0070262 | peptidyl-serine dephosphorylation | 16835242 |
| Tgene | NCK1 | GO:1902237 | positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 14676213 |
| Tgene | NCK1 | GO:1903676 | positive regulation of cap-dependent translational initiation | 11959995 |
| Tgene | NCK1 | GO:1903679 | positive regulation of cap-independent translational initiation | 11959995 |
| Tgene | NCK1 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response | 14676213 |
| Tgene | NCK1 | GO:1903912 | negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation | 14676213|16835242 |
| Tgene | NCK1 | GO:1990441 | negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 16835242 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | MESO | TCGA-XT-AASU-01A | KPNA1 | chr3 | 122215284 | - | NCK1 | chr3 | 136646826 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000344337 | ENST00000288986 | KPNA1 | chr3 | 122215284 | - | NCK1 | chr3 | 136646826 | + |
| 5CDS-5UTR | ENST00000344337 | ENST00000481752 | KPNA1 | chr3 | 122215284 | - | NCK1 | chr3 | 136646826 | + |
| 5CDS-intron | ENST00000344337 | ENST00000469404 | KPNA1 | chr3 | 122215284 | - | NCK1 | chr3 | 136646826 | + |
| intron-5UTR | ENST00000466923 | ENST00000288986 | KPNA1 | chr3 | 122215284 | - | NCK1 | chr3 | 136646826 | + |
| intron-5UTR | ENST00000466923 | ENST00000481752 | KPNA1 | chr3 | 122215284 | - | NCK1 | chr3 | 136646826 | + |
| intron-intron | ENST00000466923 | ENST00000469404 | KPNA1 | chr3 | 122215284 | - | NCK1 | chr3 | 136646826 | + |
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FusionProtFeatures for KPNA1_NCK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KPNA1 | NCK1 |